What is anti Smith antibody against?
Background: Anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE). Despite the remarkable specificity of anti-Sm antibodies for SLE, the association between anti-Sm antibody level and the clinical manifestation of SLE is still unclear.
Which antibody is most specific for SLE?
The antinuclear antibody (ANA) test is the most commonly used screening test for SLE. The presence of anti-DNA, anti-Sm, and antiphospholipid antibodies is more specific for diagnosing SLE.
What disease is indicated by a high titer of anti-SM Anti-Smith antibody?
Anti-Smith antibody has low sensitivity but high specificity for systemic lupus erythematosus (SLE). It is occasional present in mixed connective-tissue disease (MCTD). Anti-Smith antibody is more common in blacks and Asians with SLE than in whites with SLE.
What does a positive SSA antibody mean?
A positive result for SS-A/Ro antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis. A positive result for SS-A/Ro antibodies in a woman with LE prior to delivery indicates an increased risk of congenital heart block in the neonate.
What is positive ENA?
Interpretation of results for the tests included in an ENA panel are provided in the table below. A positive test result means that the person has more of that autoantibody in their blood than the designated reference value. Autoantibody Test. Results That Support an Autoimmune Disorder Diagnosis.
What is a normal range for Smith antibody?
Optimal Result: 0 – 7 U/mL. The Anti-Smith Antibody targets your body’s own proteins and is found almost exclusively in people with lupus. Though not all people with lupus have this antibody (only around 30%), those who do usually receive a diagnosis of lupus.
Is there a reference range for anti Smith antibodies?
Anti-Smith antibodies are present in some cases of systemic lupus erythematosus (SLE) and mixed connective-tissue disease (MCTD). The reference range of anti-Smith antibodies is negative. Anti-Smith antibody has low sensitivity but high specificity for systemic lupus erythematosus (SLE).
Which is anti-Smith antibody associated with disease activity?
Anti-Smith antibody is associated with disease activity in patients with new-onset systemic lupus erythematosus Although anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE), the significance of anti-Sm antibody in patients with SLE is unclear.
Is there an anti Smith antibody for SLE?
Although anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE), the significance of anti-Sm antibody in patients with SLE is unclear. This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE.
What kind of blood test is anti Smith?
Anti Smith Antibody Test. An enzyme-linked immunosorbent assay, also named ELISA or EIA, is the test that detects and measures antibodies in your blood. On the day of the test, you may to have wear a T-shirt or short-sleeved shirt to let easier contact while drawing the blood.