What does TRPV1 stand for?
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells.
Who discovered TRPV1?
David Julius
Ten years ago in 1997, the field of somatic sensory biology and pain research witnessed the breakthrough work of David Julius and colleagues that led to the cloning of the first vanilloid (capsaicin) receptor, transient receptor potential vanilloid subfamily, member 1 (TRPV1)1.
What is the TRPV1 gene?
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include Pulpitis and Somatoform Disorder. Among its related pathways are Peptide ligand-binding receptors and Ion channel transport.
Is TRPV1 a Polymodal?
The transient receptor potential vanilloid 1 (TRPV1) is characterized by its polymodal activation against chemical, thermal, mechanical, and pH-variation stimuli in neuronal cultures from human trigeminal ganglion (GT) [9], in rat and mouse dental primary afferent neurons [5, 10].
Is capsaicin a Vanilloid?
Capsaicin is the best known vanilloid ligand for TRPV1, a chemical in chili peppers that can induce cation influx and primary sensory neuronal action potentials, typically resulting in a burning sensation in mammals (Wood et al., 1988; Caterina et al., 1997).
Where are TRPV1 located?
TRPV1 receptors are found mainly in the nociceptive neurons of the peripheral nervous system, but they have also been described in many other tissues, including the central nervous system.
What is Melastatin?
(genetics, oncology) A gene expressed in melanocytes and involved in nevomelanocytic development; down-regulated in cases of melanoma.
Is capsaicin a vanilloid?
Is vanillin a Vanilloid?
The vanilloids are compounds which possess a vanillyl group. They include vanillyl alcohol, vanillin, vanillic acid, acetovanillon, vanillylmandelic acid, homovanillic acid, capsaicin, etc. Isomers are the isovanilloids.
What does TRPM5 stand for?
Transient receptor potential melastatin 5
Transient receptor potential melastatin 5 (TRPM5), a sodium-selective TRP channel, functions as a common downstream component in sweet, bitter, and umami signaling pathways.
What are Trpm channels?
TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin). Functional TRPM channels are believed to form tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8.
What is the function of the TRPV1 channel?
TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C).
Where are the TRPV1 neurons located in the body?
1 Wolfson Centre for Age Related Diseases, King’s College London, London, SE1 1UL, UK, [email protected]. TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body.
Which is the first TRPV channel to be cloned?
TRPV1 plays an important role in nociception and was the first of the TRPV family channels to be cloned. TRPV1 was cloned using capsaicin, the pungent component of hot chili pepper, by screening an expression cDNA library of dorsal root ganglia (5).
How are vanilloid receptors related to the TRPV?
TRPV. Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).