What does LAMP-1 do?
The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands.
What is the difference between LAMP-1 and lamp2?
However, LAMP-2 seems to have more specific functions since LAMP-2 single deficiency has more severe consequences than LAMP-1 single deficiency. Mutations in LAMP-2 gene cause a lysosomal glycogen storage disease, Danon disease, in humans.
What is LAMP-1 a marker for?
Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system. Autophagy.
What is the purpose of stratum corneum?
The skin barrier is located in the uppermost layer of the skin, the stratum corneum (SC; fig. 1). Its function is to protect the body from excessive transepidermal water loss (TEWL), as well as to prevent the penetration of compounds into the body via the epidermis.
What is lysosomal marker?
Lysosomes are membrane-bound organelles essential to cell metabolism. Lysosome marker antibodies can aid in the study of lysosome structure and functions. Lysosome marker antibodies can also help elucidate the role or roles a protein may play in a number of tasks that are centered in or influenced by the lysosome.
What is Kferq motif?
The “pure” KFERQ motif is only present in ribonuclease A, the first protein identified as a CMA substrate. Sequence analysis revealed that KFERQ-like motifs are present in about 30% of cytosolic soluble proteins. The CMA motif is rarely present in proteins in organelles or membrane proteins.
What is CMA disease?
Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across the lysosome membrane for degradation.
What do corneocytes do?
Functions. Layers of corneocytes produce high mechanical strength which allows epidermis of the skin to perform its function as a physical, chemical and immunological barrier. Corneocytes are also capable of absorbing and storing small amounts of water to keep the skin hydrated and maintain its flexibility.
What is the lipid barrier?
Also known as the Skin Barrier or Moisture Barrier, the Lipid Barrier is found in the Stratum Corneum of our skin. The Stratum Corneum is the outermost layer of the epidermis and consists of corneocytes (layers of dead skin cells) and lipids (the skin’s natural fats). Dr.
What is the medical definition of a lamella?
lamel´lae [L.] 1. a thin leaf or plate, as of bone. 2. a medicated disk or wafer to be inserted under the eyelid. circumferential lamella one of the layers of bone that underlie the periosteum and endosteum.
What kind of structure is the lamellar structure?
The primary lamellar structure consisting of planar, extremely flat and highly coherent interfaces results from the γ-lamellae through the ledge mechanism. The solute supersaturation in the α 2 /α phase is primarily responsible for providing the driving force for the thickening of the γ-plates.
Which is the best description of a circumferential lamella?
circumferential lamella one of the bony plates that underlie the periosteum and endosteum. concentric lamella haversian lamella. endosteal lamella one of the bony plates lying beneath the endosteum.
How is the head connected to the lamella?
Historical Examples of lamella In this way the organs developed between the two layers of the lamella obtain their final fixed position. The head is also more or less connected by a thin plate of bone, the lamella, to another outgrowth, the processus longus.