What does complex II do in oxidative phosphorylation?
oxidative phosphorylation. Complex II is another group of proteins that serves as a second entry point into the electron transport chain, which is involved in the additional production of ATP to power cellular processes.
What is oxidized Complex 2?
Succinate-Q oxidoreductase, also known as complex II or succinate dehydrogenase, is a second entry point to the electron transport chain. It is unusual because it is the only enzyme that is part of both the citric acid cycle and the electron transport chain. It oxidizes succinate to fumarate and reduces ubiquinone.
What is oxidative phosphorylation in simple terms?
Definition of oxidative phosphorylation : the synthesis of ATP by phosphorylation of ADP for which energy is obtained by electron transport and which takes place in the mitochondria during aerobic respiration.
What is the role of complex 2?
Complex II is a component of both the Krebs cycle and the respiratory chain [3]. Complex II oxidizes the Krebs cycle intermediate succinate, generating fumarate by passing electrons from succinate to FAD. Although the enzyme containe a heme iron, its role in electron transfer is uncertain.
What is oxidative phosphorylation also known as?
Oxidative phosphorylation is also known as the electron transport chain. It includes the reactions that result in the synthesis of ATP from ADP + Pi. Heat can also be generated when ATP production is uncoupled from the respiratory chain.
Why is it called oxidative phosphorylation?
In the mitochondrion, what the proton gradient does is facilitate the production of ATP from ADP and Pi. This process is known as oxidative phosphorylation, because the phosphorylation of ADP to ATP is dependent on the oxidative reactions occurring in the mitochondria.
What type of protein is complex 2?
Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and CybS), as well as prosthetic groups required for electron transfer from succinate to ubiquinone.
How does Complex II participate in oxidative phosphorylation?
The four subunits together form a ubiquinone-binding site. Complex II participates in both the citric acid cycle and in oxidative phosphorylation. Therefore, it becomes a parallel route for electrons to reach the quinone pool, and FAD receives high-energy electrons from the products of fatty acid metabolism.
What is the electron transport chain of oxidative phosphorylation?
The electron transport chain of oxidative phosphorylation involves four major protein complexes, (numbered I, II, III and IV) each with increasing reduction potentials. In essence, as the electron moves from one protein complex to the next, it travels towards molecules that have a greater affinity for electrons.
How does the uncoupler inhibit oxidative phosphorylation?
Uncouplers inhibit oxidative phosphorylation. They ‘uncouple’ the ETC from oxidative phosphorylation. The ETC remains intact and electrons are transferred to Oto 2
How is water formed in oxidative phosphorylation?
Its important to note that oxygen must be present for oxidative phosphorylation to occur. Water is formed as oxygen receives the electrons from protein complex 4, and combines with protons on the inside of the cell. 2. Phosphorylation – the production of ATP