What does BCR-ABL test mean?
A BCR-ABL genetic test looks for a genetic mutation (change) on a specific chromosome. Chromosomes are the parts of your cells that contain your genes. Genes are parts of DNA passed down from your mother and father. They carry information that determines your unique traits, such as height and eye color.
What blood test shows CML?
Most people are diagnosed with CML through a blood test called a complete blood count (CBC) before they have any symptoms. A CBC counts the number of different kinds of cells in the blood. A CBC is often done as part of a regular medical checkup. People with CML have high levels of white blood cells.
What is BCR in Philadelphia chromosome?
A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The BCR-ABL gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the Philadelphia chromosome.
What type of inhibitor is imatinib Gleevec?
Abstract. Imatinib mesylate (Gleevec, Glivec, Novartis) is a selective inhibitor of ABL, ARG, KIT, PDGFR, and some oncogenic forms, most notably BCR-ABL. Accelerated approval was initially granted by the Food and Drug Administration (FDA) in 2001 for the treatment of Ph+CML after the failure of IFNα therapy.
How high is WBC in CML?
Laboratory features. Peripheral blood The most common feature of CML is an elevated WBC count, usually > 25 × 109/L and frequently > 100 × 109/L, occasionally with cyclic variations.
What do you need to know about BCR-ABL1?
The quantitative BCR-ABL1 molecular test measures either of the breakpoints in the fusion gene. It is used to establish a baseline value and then to monitor the person’s response to treatment and, if the person achieves remission, to monitor for recurrence.
What does BCR-ABL1 mean for imatinib resistance?
If the BCR-ABL1 level rises, then it indicates disease progression or recurrence and it may also indicate that the person has become resistant to imatinib. Additional genetic testing is often performed to detect the development of BCR-ABL1 kinase domain mutations associated with imatinib resistance.
Where is the BCR-ABL1 fusion gene located?
The resulting chromosome 22 that has the BCR-ABL1 gene sequence is known as the Philadelphia (Ph) chromosome because that is where it was first discovered. The resulting Philadelphia chromosome contains an abnormal BCR-ABL1 fusion gene that encodes an abnormal protein that is responsible for the development of CML and a type of ALL.
Is the BCR-ABL1 major ( P210 ) a quantitative test?
May include related or preferred tests. This quantitative test is appropriate for diagnosis and therapeutic monitoring for CML or ALL. The BCR-ABL1 major (p210) fusion forms are present in almost all cases of CML and in a small subset of cases of ALL.