What cells have CD52?
CD52 is a 12 amino acid GPI-linked protein with a large N-linked glycan moiety, expressed widely across immune cells including T and B cells, monocytes, macrophages and eosinophils (11, 12).
What is the function of CD52?
CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.
What is anti CD52?
Anti-CD52 Antibody is a non-therapeutic biosimilar of the monoclonal antibody drug alemtuzumab (Lemtrada) for research use. It can be used in bioanalytical assays and for studying biological pathways affected by the drug. Product Type Monoclonal Antibody Clone Campath-1H Isotype IgG1.
Is lemtrada a monoclonal antibody?
LEMTRADA is a monoclonal antibody that selectively binds to CD52, highly expressed on lymphocytes (T and B cells), depleting these cells from circulation in the periphery. Other immune cells in the periphery have lower CD52 expression and are minimally affected.
What are the side effects of alemtuzumab?
The most common side effects of LEMTRADA include:
- rash.
- headache.
- thyroid problems.
- fever.
- swelling of your nose and throat.
- nausea.
- urinary tract infection.
- feeling tired.
What cells express CD20?
CD20 (cluster of differentiate 20) is a protein that is expressed on the surface of B cells, starting at the pre-B cell stage and also on mature B cells in the bone marrow and in the periphery.
Who makes Campath?
Campath as medication was first approved for B-cell chronic lymphocytic leukemia in 2001. It is marketed by Genzyme, which acquired the worldwide rights from Bayer AG in 2009. Genzyme was bought by Sanofi in 2011.
What targeted binds with CD52?
Conclusions: Expression of CD52 by the pathologic LC’s seen in LCH suggests that alemtuzumab may represent a new, targeted therapy for this disease. Such therapy is particularly needed for patients with refractory, high-risk disease.
What is anti CD20 monoclonal antibody?
Anti-CD20 monoclonal antibodies (mAbs) are used to achieve B cell depletion, and were initially developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
What is lemtrada made from?
Alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa monoclonal antibody that is directed against the 21–28 kDa cell surface glycoprotein CD52.
What is lemtrada?
Lemtrada works by binding to and killing immune cells (lymphocytes or white blood cells) which are involved when the immune system attacks myelin. It is thought that the immune cells which grow back after treatment do not cause damage to nerves.
How much does alemtuzumab cost?
| Drug/Comparator | Strength | Pricea ($) |
|---|---|---|
| Alemtuzumab (Lemtrada) | 12 mg/1.2 mL solution for infusion | 1,045.8333 per mg |
| Natalizumab (Tysabri) | 300 mg/15 mL solution for infusion | 3,295.8900 |
| Oral therapies | ||
| Dimethyl fumarate (Tecfidera) | 120 mg 240 mg | 16.8464 33.6929 |
Is the CD52 protein detectable in stem cells?
CD52 is a protein present on a cell surface of the vast majority of all lymphoid cells and many other hematopoietic cells but not on stem cells. This antigenis a target for monoclonal antibody therapy (Campath). This antigen is currently not detectable in formalin-fixed, paraffin-embedded material but can be detected by flow cytometry.
Where is the glycoprotein CD52 found in the body?
CD52 is a GPI-anchored glycoprotein, expressed in the hematopoietic system on B and T cells, monocytes, macrophages, eosinophils, natural killer cells, and dendritic cells ( 1, 2) and in the male reproductive tract by epithelial cells of the epididymis from which it is released into the seminal fluid to be taken up by sperm ( 3, 4 ).
Where is CD52 found on a sperm cell?
CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes and dendritic cells. Further, it is found within the male genital tract and is present on the surface of mature sperm cells.
What is the function of the peptide CD52?
CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.