What causes Macroovalocytes?
In most instances, the macroovalocyte morphology is due to megaloblastic erythropoiesis (Vitamin B-12 or folate deficiency) but may be seen with dyserythropoiesis. Although macroovalocytes are characteristic in these deficiency states, they are not pathognomonic.
What causes megaloblastic?
Usually, megaloblastic anemia is due to acquired deficiency in vitamin B12 or folic acid. The deficiency can be related to inadequate dietary intake of these B vitamins or poor intestinal absorption.
What are Macrocytes?
Macrocytosis is a term used to describe red blood cells that are larger than normal. Also known as megalocytosis or macrocythemia, this condition typically causes no signs or symptoms and is usually detected incidentally on routine blood tests.
What is a Polychromatophil?
The polychromatophil is an immature red blood cell which has already lost its nucleus. An elevated number of polychromatophils suggests an increased production of erythrocytes by the bone marrow (erythroid hyperplasia) in response to anemia.
What are oval Macrocytes?
Oval macrocytes are most commonly associated with vitamin B-12 and/or folic acid deficiency. Decreased DNA synthesis causes the nucleus in the developing red cells to mature at a slower than normal rate.
What is pathophysiology of megaloblastic anemia?
Pathophysiology. The pathophysiology of this group of anemia is ineffective erythropoiesis secondary to intramedullary apoptosis of hematopoietic cell precursors, which results from DNA synthesis abnormalities. Both vitamin B12 and folate deficiencies may cause defective DNA synthesis.
What is megaloblastic Anaemia?
Megaloblastic anemia is a condition in which the bone marrow produces unusually large, structurally abnormal, immature red blood cells (megaloblasts). Bone marrow, the soft spongy material found inside certain bones, produces the main blood cells of the body -red cells, white cells, and platelets.
What causes Microcytosis?
The most common causes of microcytosis are iron deficiency anemia and thalassemia trait. Other diagnoses to consider include anemia of chronic disease, lead toxicity, and sideroblastic anemia. Serum ferritin measurement is the first laboratory test recommended in the evaluation of microcytosis.