Is ellagic acid soluble in water?
Ellagic acid (EA) is a bioactive natural polyphenol with antioxidant and several other beneficial properties, but unfortunately it cannot be exploited for in vivo therapeutic applications because of its poor water solubility and accordingly low bioavailability.
How do you extract ellagic acid?
Ellagic acid was extracted from freeze-dried berries, pears, peaches, plums, grapes, apples, kiwi, and several nuts using either acetone/water or methanol. The extracts were treated with trifluoroacetic acid to hydrolyze the ellagic acid glucosides, and analyzed by high-performance liquid chromatography (HPLC).
What does ellagic acid dissolve in?
Ellagic acid is soluble in DMSO, which should be purged with an inert gas. The solubility of ellagic acid in DMSO is approximately 0.14 mg/ml. Ellagic acid is sparingly soluble in aqueous buffers. An aqueous solution can best be prepared by diluting the organic solution into aqueous buffers or isotonic saline.
What is ellagic acid used for?
Ellagic acid is a naturally occurring substance. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, and walnuts. Medicinally, ellagic acid is used to prevent cancer and treat viral and bacterial infections.
What is the pH of ellagic acid?
UV/Vis spectra of ellagic acid (c EA = 1 9 10 -5 M) in aqueous solutions of different pH values (given on figure): a pH range 1.13–5.70, b pH range 6.09–9.57, and c pH range 10.02–12.54; t = 25 ± 1 °C; scan rate 500 nm/min.
Is ellagic acid a flavonoid?
7 Ellagic Acid Ellagic acid (Fig. 3), a polyphenol found in fruits and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, wolfberry, and other plant foods, is a highly investigated phytochemical. It possesses anti-oxidant, anti-mutagenic, and anticancer properties.
What contains ellagic acid?
Ellagic acid is a naturally occurring substance. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts.
How much ellagic acid is in pomegranate juice?
Pomegranate juice had the highest concentration of ellagic acid, 103 mg/L, while the other juices ranged from 1 mg/L to 2 mg/L. The 3:1 pomegranate-cranberry mixture had the highest EA concentration of 97 mg/L of all juice combinations. Polyphenols are a broad family of natural compounds widely found in plant foods.
Is ellagic acid safe?
Ellagic acid is safe when consumed as part of a healthy diet. However, ellagic acid supplements may interfere with certain medications by blocking the action of a specific group of enzymes.
What is ellagic acid in skin care?
Ellagic acid is a naturally occurring polyphenol compound found in plants and is a powerful antioxidant. Ellagic acid (EA) is a type of antioxidant referred to as a “polyphenol”. Ellagic Acid in a topical form assists in the fighting fine lines and wrinkles, among other benefits.
Is ellagic acid good for hair?
Finding of histopathological studies supported the fact that ellagic acid have excellent hair growth promoting activity by an enlargement of follicular size and a prolongation of the anagen phase. This study discovers the possible use of ellagic acid in treatments of androgenic alopecia.
What does niacinamide do to your skin?
Niacinamide reduces inflammation , which may help ease redness from eczema, acne, and other inflammatory skin conditions. Minimizes pore appearance. Keeping skin smooth and moisturized may have a secondary benefit — a natural reduction in pore size over time. Regulates oil.
Is there an appropriate dose of ellagic acid?
We currently have no information for ELLAGIC ACID overview. The appropriate dose of ellagic acid depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ellagic acid.
What kind of reaction does ellagic acid have?
ELLAGIC ACID reacts as a weak acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated. Heat is also generated by the acid-base reaction between phenols and bases.
Why do people take ellagic acid by mouth?
Some people take ellagic acid by mouth for cancer, mental function, and viral or bacterial infections. Ellagic acid is applied to the skin as a lightening agent. How does it work? Ellagic acid may bind to chemicals that cause cancer, and it may also prevent the growth of cancer cells.
What foods are the best sources of ellagic acid?
Ellagic acid is a naturally occurring substance. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts. Some people take ellagic acid by mouth for cancer, mental function, and viral or bacterial infections. Ellagic acid is applied to the skin as a lightening agent.