Is Ehlers-Danlos syndrome dominant or recessive?
The 2 main ways EDS is inherited are: autosomal dominant inheritance (hypermobile, classical and vascular EDS) – the faulty gene that causes EDS is passed on by 1 parent and there’s a 50% risk of each of their children developing the condition.
Which type of collagen is primarily affected by Ehlers-Danlos syndrome?
Classical Ehlers-Danlos syndrome (EDS) is characterized by skin hyperelasticity, joint hypermobility, increased tendency to bruise, and abnormal scarring. Mutations in type V collagen, a regulator of type I collagen fibrillogenesis, have been shown to underlie this type of EDS.
Is Ehlers-Danlos syndrome Autoimmune?
A much rarer group of connective tissue disorders is called Ehlers-Danlos syndrome. Unlike the diseases noted above, Ehlers-Danlos syndrome is not an autoimmune condition, it’s an inherited disorder.
Who is most likely to get Ehlers-Danlos syndrome?
Most are rare e.g., 1 in 40,000 – 200,000 and some are ultrarare i.e., less than 1 in a million people. Individuals of all racial and ethnic backgrounds are affected by EDS which can present with complications from birth and progress over time.
Can people with Ehlers-Danlos have children?
Overall, pregnancy is well tolerated in hEDS. Possible complications are mainly attributable to joint hypermobility, skin and tissue fragility and abnormal collagen in blood vessels. It is generally a benign condition and the majority of women tolerate pregnancy well with good outcomes.
Does EDS affect the eyes?
Ehlers Danlos Syndrome patients are prone to myopia and elongated eyes due to the stretching of the collagenous sclera.
Can you donate blood if you have Ehlers-Danlos syndrome?
Certain medications may delay your ability to donate blood….Medical Conditions Affecting Donation.
| Medical Conditions | Eligibility |
|---|---|
| Ehlers Danlos Syndrome | Acceptable |
| Ehrlichiosis | Accept if asymptomatic and treatment completed |
Does EDS affect periods?
Menstruation with EDS A survey of women with EDS reported that only 32.8% of patients had a normal menstrual cycle. About 18% of patients had bleeding between periods. Nearly 33% of patients had a heavy menstrual flow. The vast majority of participants (92.5%) experienced painful cramps during menstruation.