How do you give plerixafor?
Administering Mozobil
- Begin treatment with Mozobil after the patient has received G-CSF once daily for 4 days1
- Administer Mozobil approximately 11 hours prior to initiation of each apheresis session for up to 4 consecutive days1
What is the drug plerixafor used for?
Plerixafor is used by patients with certain types of cancer (non-Hodgkin’s lymphoma-NHL, multiple myeloma-MM) to prepare them for stem cell transplant. Stem cells, which are found mainly in the bone marrow, turn into red blood cells, white blood cells, and platelets.
When is plerixafor administered?
Plerixafor injection comes as a liquid to be injected subcutaneously (under the skin) by a doctor or nurse in a medical facility. It is usually injected once a day, 11 hours before the removal of blood cells, for up to 4 days in a row.
How long does Mozobil stay in your system?
In pharmacodynamic studies of Mozobil in conjunction with G-CSF in healthy volunteers, a sustained elevation in the peripheral blood CD34+ count was observed from 4 to 18 hours after plerixafor administration with a peak CD34+ count between 10 and 14 hours.
How do you administer Mozobil?
Administer Mozobil approximately 11 hours prior to initiation of each apheresis for up to 4 consecutive days. The recommended dose of Mozobil by subcutaneous injection is based on body weight: • 20 mg fixed dose or 0.24 mg/kg of body weight for patients weighing ≤83 kg.
How do you inject Mozobil?
Mozobil is to be administered as a subcutaneous injection approximately 11 hours prior to the start of each apheresis session for up to 4 consecutive days.
Is Plerixafor a chemotherapy?
Plerixafor is a more effective and less toxic mobilising agent than conventional chemotherapy (especially in heavily pretreated patients), with comparable subsequent outcome, and merits consideration as the first-line standard of care for stem cell mobilisation.
How is Aldesleukin administered?
Aldesleukin comes as a powder to be mixed with liquid to be injected over intravenously (into a vein) over 15 minutes by a doctor or nurse in a hospital. It is usually injected every 8 hours for 5 days in a row (a total of 14 injections). This cycle may be repeated after 9 days.
How much does Plerixafor cost?
The average wholesale package price for one 1.2-mL vial of plerixafor is $8652.68.
How does G CSF work?
Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.
Is Plerixafor a chemo drug?
Where is mozobil administered?
How is the dosage of plerixafor calculated for patients?
-The dosing has been calculated based on actual patient body weight up to 175% of ideal body weight; dosing and treatment of patients weighing more than 175% of ideal body weight have not been investigated.
How many doses of Benadryl can you take in 24 hours?
Do not take more than 6 doses in 24 hours. Use only as directed. Do not take more than 6 doses in 24 hours. Use only as directed.
How much Plerixafor is in one ml of Mozobil?
Mozobil (plerixafor) injection is a sterile, preservative-free, clear, colorless to pale-yellow, isotonic solution for subcutaneous injection. Each mL of the sterile solution contains 20 mg of plerixafor. Each single-use vial is filled to deliver 1.2 mL of the sterile solution that contains
When to take plerixafor for non Hodgkin’s lymphoma?
Usual Adult Dose for non-Hodgkin’s Lymphoma. Dosing Based on Actual Patient Body Weight: -83 kg or Less: 20 mg fixed dose or 0.24 mg/kg subcutaneously once in the evening, approximately 11 hours prior to initiation of each apheresis.