Can teicoplanin cause thrombocytopenia?
Teicoplanin, a new glycopeptide antibiotic, is structurally related to ristocetin, an antibiotic known to induce human platelet agglutination and, thus, thrombocytopenia and thromboembolic side effects.
Which antibiotics can cause low platelets?
Some prescribed medications can also cause thrombocytopenia, including:
- amiodarone.
- ampicillin and other antibiotics.
- cimetidine.
- piperacillin.
- seizure medications, such as carbamazepine.
- sulfonamides, such as trimethoprim-sulfamethoxazole.
- vancomycin.
Why do antibiotics cause thrombocytopenia?
Vancomycin-induced thrombocytopenia is thought to occur through a hapten-drug mechanism because vancomycin binds to platelet glycoproteins, leading to the generation of antibodies that bind to the platelet surface and cause cell lysis.
Can antibiotics cause thrombocytopenia?
Antibiotic-induced immune thrombocytopenia (AIT) is a rare postoperative complication that can develop after the use of commonly used antibiotics in total joint arthroplasty.
What are the side effects of teicoplanin?
Common adverse effects include rashes, fever, pruritus, diarrhoea, nausea and vomiting. Ototoxicity has been reported so auditory function should be monitored if other neurotoxic drugs, e.g. aminoglycosides, are being given or treatment is prolonged in a patient with renal insufficiency.
Can meropenem cause thrombocytopenia?
Conclusions: Drug-induced immune thrombocytopenia should be considered in cases of acute thrombocytopenia in patients undergoing meropenem treatment. Clinicians should be cognizant of DITP, and a definitive diagnosis should be pursued, if feasible.
Can antidepressants cause low platelet count?
Selective serotonin re-uptake inhibitors (SSRI) have inhibitory effects on 5-HTT and 5-HT receptors of platelets, thereby diminishing platelet aggregation. There have been many reports of SSRI causing reductions in platelet count and sometimes resulting in thrombocytopenia.
What drugs can cause thrombocytopenia?
Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia….Other medicines that cause drug-induced thrombocytopenia include:
- Furosemide.
- Gold, used to treat arthritis.
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Penicillin.
- Quinidine.
- Quinine.
- Ranitidine.
- Sulfonamides.
Which drug is likely cause of thrombocytopenia?
Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia. If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia.
What happens if you shake teicoplanin?
Do not shake the vial as the solution will form a foam. If the solution does foam, leave it to stand, the foam will take 10 – 15 minutes to reduce. Only draw up when the foam has settled.
Which is the most common side effect of teicoplanin?
The most common side effects associated with teicoplanin are maculopapular or erythematous rash and drug-related fever in around 7% and 6% of the patients, respectively132; these are more frequent in patients receiving doses of more than 12 mg/kg/day.
How many Glycopeptides are there in teicoplanin?
Teicoplanin is a glycopeptide antibiotic that is made up of five major compounds (teicoplanin A2-1 through A2-5) and four minor compounds (named teicoplanin RS-1 through RS-4). Teicoplanins all have the same glycopeptide core, teicoplanin A3-1, but their side chains attached to their -D-glucosamine moiety differ in length and conformation.
Is there a cross reaction between vancomycin and teicoplanin?
Cases of allergic cross-reactions between vancomycin and teicoplanin have been reported, but vancomycin-allergic patients also have been successfully treated with teicoplanin.
How does teicoplanin work to treat renal insufficiency?
Teicoplanin is 90% bound to plasma proteins, and it is primarily eliminated by renal excretion; since clearance is predictably reduced in renal insufficiency, dosage adjustments can be made on the basis of the ratio of impaired clearance to normal clearance. Steady state concentrations are reached more slowly with increasing renal impairment.