Can isoniazid cause psychosis?
Isoniazid, as part of DOTS regimen, is the first line of drug and very commonly used. Adverse effects include hepatitis, peripheral neurotoxicity, lupus like syndrome, and central nervous system effects including dysarthria, seizures, irritability and even psychosis [2].
What are the signs and symptoms of drug induced psychosis?
Some of the symptoms of drug induced psychosis include:
- Paranoia.
- Delusions.
- Auditory and visual hallucinations.
- Anti-social behaviour.
- Panic attacks.
- Confusion.
Can ethambutol cause psychosis?
Clinically, ethambutol (EMB)-induced psychosis is rare. In our review of the literature, most cases of antituberculosis agent-associated psychoses were caused by isoniazid (INH).
Which TB drugs cause psychosis?
Drugs such as isoniazid, cycloserine, ethambutol and flouroquinolones used in the treatment of tuberculosis have been reported to produce drug-induced psychosis. Madan et al17 have reported a case of suicidal attempt in a patient on isoniazid treatment, who had attempted 4 days after the onset of psychosis.
Does rifampicin cause psychosis?
An initial diagnosis of drug-induced psychosis was made after a psychiatric consultation, with isoniazid being identified as the likely culprit….Table 1.
| Days | Drug given | Appearance of psychotic symptoms |
|---|---|---|
| Day 12 | Rifampicin 150 mg | No |
| Day 13 | Rifampicin 300 mg | No |
| Day 14 | Rifampicin 450 mg | No |
How does isoniazid cause pellagra?
Pellagra is caused by cellular deficiency of niacin or its precursor amino acid, tryptophan. Isoniazid preventive therapy (IPT) is the administration of isoniazid (INH) to latent tuberculosis (TB) infection affected people preventing advancement to active TB disease.
What happens if psychosis goes untreated?
Untreated psychosis symptoms can impact all areas of a person’s life, leading to significant impairment at work, at home, at school, in relationships, and with society at large. People with psychosis may not be able to take care of themselves properly.