Are there any dose-adjusted EPOCH-R therapies?
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study Cancer Trials Support Unit and Center for Cancer Research of the National Cancer Institute and Genentech.
Are there any phase 2 trials for EPOCH-rituximab?
We conducted a single-group, phase 2, prospective study of infusional dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine, prednisone, and rituximab (DA-EPOCH-R) and filgrastim without radiotherapy in 51 patients with untreated primary mediastinal B-cell lymphoma.
Which is better R-CHOP or DA-EPOCH-R?
In the 50303 study population, the more intensive, infusional DA-EPOCH-R was more toxic and did not improve PFS or OS compared with R-CHOP. The more favorable results with R-CHOP compared with historical controls suggest a potential patient selection bias and may preclude generalizability of results …
What are the primary endpoints of DA-EPOCH-R?
DA-EPOCH-R was scheduled to be administered with CNS prophylaxis for six cycles. Primary endpoints included event-free and overall survival. This study is registered with ClinicalTrials.gov (NCT01092182).
Which is better DA-EPOCH-R or R-CHOP?
In the 50303 study population, the more intensive, infusional DA-EPOCH-R was more toxic and did not improve PFS or OS compared with R-CHOP. The more favorable results with R-CHOP compared with historical controls suggest a potential patient selection bias and may preclude generalizability of results to specific risk subgroups.
How are dose adjustments used in EPOCH chemotherapy?
Dose adjustments are a fundamental component of the EPOCH regimen. Adjustments above the starting-dose level always applied to etoposide, doxorubicin, and cyclophosphamide; and adjustments below the starting-dose level applied only to cyclophosphamide. All drug doses were based on true body weight.