Which antibiotic is consistently active against anaerobic gram-negative rods?
Metronidazole is highly active against gram-negative anaerobic bacteria, such as B. fragilis, and gram-positive anaerobic bacteria, such as C. difficile. The pharmacokinetic and pharmacodynamic properties of the drug are favorable, and it is available as oral, intravenous, vaginal, and topical formulations.
What antibiotics have anaerobic coverage?
The most effective antimicrobials against anaerobic organisms are metronidazole, the carbapenems (imipenem, meropenem and ertapenem), chloramphenicol, the combinations of a penicillin and a beta-lactamase inhibitor (ampicillin or ticarcillin plus clavulanate, amoxicillin plus sulbactam, and piperacillin plus tazobactam …
What antibiotics cover gram-negative rods?
These antibiotics include cephalosporins (ceftriaxone-cefotaxime, ceftazidime, and others), fluoroquinolones (ciprofloxacin, levofloxacin), aminoglycosides (gentamicin, amikacin), imipenem, broad-spectrum penicillins with or without β-lactamase inhibitors (amoxicillin-clavulanic acid, piperacillin-tazobactam), and …
What antibiotic kills anaerobic bacteria?
Metronidazole is selectively active against anaerobic bacteria, including colonic Gram negative Bacteroides spp.
What antibiotics treat gram-negative anaerobes?
Drugs active against essentially all Gram-negative (and other) anaerobes are metronidazole, imipenem, chloramphenicol, and combinations of β-lactam drugs plus a β-lactamase inhibitor.
Which antibiotics are best for gram-negative bacteria?
Fourth-generation cephalosporins such as cefepime, extended-spectrum β-lactamase inhibitor penicillins (piperacillin/tazobactam, ticarcillin/clavulanate) and most importantly the carbapenems (imipenem/cilastatin, meropenem, ertapenem) provide important tools in killing Gram-negative infections.
Are anaerobic bacteria gram-negative?
Anaerobic Gram-negative bacilli are common elements of the mucous membrane flora throughout the body; they often act as secondary pathogens. They are the most common anaerobes involved in infection and include some of the most antibiotic-resistant species.
Does azithromycin cover gram-negative rods?
Azithromycin is a broad-spectrum macrolide antibiotic with bacteriostatic activity against many Gram-positive and Gram-negative bacteria including Bordetella pertussis and Legionella species. It also has activity against Mycoplasma pneumoniae, Treponema pallidum, Chlamydia species and Mycobacterium avium complex.
What are Gram-negative anaerobes?
Are gram-negative rods anaerobic?
What are aerobic Gram negative bacilli?
Description of Gram-Negative Aerobic Bacteria. Gram-Negative Aerobic Bacteria: A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine. Source: MeSH 2007.
What antibiotic is used for Gram positive cocci?
Penicillin G is most effective for treating anaerobic gram-positive cocci and microaerophilic streptococci. Other effective agents include other penicillins , cephalosporins, chloramphenicol , clindamycin, vancomycin , telithromycin, linezolid , quinupristin/dalfopristin, and carbapenems.
Does clindamycin cover Pseudomonas?
Most aerobic Gram-negative bacteria (such as Pseudomonas, Legionella, Haemophilus influenzae and Moraxella) are resistant to clindamycin, as are the facultative anaerobic Enterobacteriaceae. A notable exception is Capnocytophaga canimorsus, for which clindamycin is a first-line drug of choice.