What labs should be monitored for nephrotoxicity?
Nephrotoxicity can be diagnosed through a simple blood test. Evaluation of nephrotoxicity through blood tests includes the measurements of blood urea nitrogen (BUN), concentration of serum creatinine, glomerular filtration rate and creatinine clearance.
Which ARV drug is associated with renal toxicity?
Some antiretroviral agents, and particularly tenofovir, have been associated with nephrotoxic drug effects, including decline in glomerular filtration rate, proximal tubular damage, and acute kidney injury.
What drugs show nephrotoxicity?
Drugs Associated with Nephrotoxicity
| Drug class/drug(s) | Pathophysiologic mechanism of renal injury |
|---|---|
| Haloperidol (Haldol) | Rhabdomyolysis |
| Pamidronate (Aredia) | Glomerulonephritis |
| Phenytoin (Dilantin) | Acute interstitial nephritis |
| Quinine (Qualaquin) | Thrombotic microangiopathy |
Can HIV meds cause kidney problems?
Some HIV medicines can affect the kidneys. Health care providers carefully consider the risk of kidney damage when recommending specific HIV medicines to include in an HIV treatment regimen. Kidney disease can advance to kidney failure. The treatments for kidney failure are dialysis and a kidney transplant.
What lab values indicate kidney function?
A creatinine level of greater than 1.2 for women and greater than 1.4 for men may be an early sign that the kidneys are not working properly. As kidney disease progresses, the level of creatinine in the blood rises. This test is a measure of how well the kidneys are removing wastes and excess fluid from the blood.
Is lamivudine nephrotoxic?
Background: Lamivudine is one of the anti-hepatitis B virus (HBV) agents to prevent HBV recurrence after transplantation because lamivudine is safe for long-term use. However, nephrotoxicity is one of the adverse effects of lamivudine.
Is tenofovir nephrotoxic?
Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial.
What are the clinical manifestations of nephrotoxicity?
If severe enough, nephrotoxicity can show signs of other types of decreased kidney function, such as decreased urination, swelling from fluid retention and high blood pressure. In some patients, nephrotoxicity can also affect other body systems such as the liver or the skin and show signs in those areas as well.
What STD causes kidney problems?
The adolescent population is particularly vulnerable to STDs. Those that cause significant kidney disease are of viral origin. The primary VVD are HIV-1, HBV, and HCV.
Are antivirals nephrotoxic?
The exact frequency of nephrotoxicity induced by antiviral drugs is difficult to determine. Antiviral drugs cause renal failure through a variety of mechanisms. Direct renal tubular toxicity has been described with a number of new medications with unique effects on epithelial cells of the kidney.