What is vimentin gene?
VIM (Vimentin) is a Protein Coding gene. Diseases associated with VIM include Cataract 30, Multiple Types and Cataract 30. Among its related pathways are ERK Signaling and Apoptotic cleavage of cellular proteins.
What is vimentin a marker for?
In recent years, vimentin has been recognized as a marker for epithelial-mesenchymal transition (EMT). Although EMT is associated with several tumorigenic events, vimentin’s role in the underlying events mediating these processes remains unknown.
What is the difference between genome chromosome gene and DNA?
Genes are made of DNA, and so is the genome itself. A gene consists of enough DNA to code for one protein, and a genome is simply the sum total of an organism’s DNA. DNA is long and skinny, capable of contorting like a circus performer when it winds into chromosomes.
What is a gene chromosome DNA?
Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body. Chromosomes are structures within cells that contain a person’s genes. Genes are contained in chromosomes, which are in the cell nucleus.
Is vimentin a mesenchymal marker?
Vimentin is one type of EMT protein marker, which is present in mesenchymal cells and involved in cancer progression [4, 7, 11, 15].
What vimentin mean?
Vimentin, also known as fibroblast intermediate filament, is the major intermediate filament found in nonmuscle cells (Colvin et al., 1995). These cell types include fibroblast, endothelial cells, macrophages, melanocytes, Schwann cells, and lymphocytes.
What is a genome vs Gene?
A genome is all of the genetic material in an organism. It is made of DNA (or RNA in some viruses) and includes genes and other elements that control the activity of those genes.
What cells express vimentin?
Vimentin is a widely expressed and highly conserved 57-kD protein that is constitutively expressed in mesenchymal cells, including endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes (3–8).
Is vimentin expressed in neurons?
Vimentin is expressed by neurons in AD brain regions exhibiting intracellular and extracellular amyloid. Sections were double-immunostained for vimentin (red) and Aβ42 (blue).
How does vimentin play a role in breast cancer?
MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis. Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli. COPB2 is up-regulated in breast cancer and plays a vital role in the metastasis via N-cadherin and Vimentin.
What are the roles of vimentin and peripherin?
Desmin, Glial Fibrillary Acidic Protein, Vimentin, and Peripherin are type III intermediate filaments that have roles in health and disease [review] Silencing of Vimentin in CNE2 cells leads to a decrease of microvessel density and VEGF, CD31, MMP2, and MMP9 expressions in pulmonary metastatic tumors.
What does vimentin do for amoeboid cancer cells?
A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments. Vimentin prevents a miR-dependent negative regulation of tissue factor mRNA during epithelial-mesenchymal transitions and facilitates early metastasis.
What is the role of vimentin in renal cell carcinoma?
Vimentin plays an important role in hypoxia induced Vasculogenic mimicry formation of renal cell carcinoma (RCC) cells and targeted Vimentin might be beneficial for RCC therapy Results find that VIM overexpression was significantly correlated with poor disease-free and overall survival of patients with lung adenocarcinoma.