What is the primary reason for using magnetic nanoparticles in drug delivery?
Nanoparticles are more reactive than bulk materials due to their high surface to volume ratio (Klabunde 1996). As a result, these magnetic core nanomaterials need to be protected against corrosion. This coating also prevents the leaching of potentially toxic components into the body during in vivo applications.
How nanoparticles are used as targeted drug delivery?
Nanoparticles can cross the blood-brain barrier following the opening of endothelium tight junctions by hyper-osmotic mannitol, which may provide sustained delivery of therapeutic agents for difficult-to-treat diseases like brain tumors (Kroll et al., 1998).
Which nanoparticles are used in drug delivery?
Nanoparticles used in drug delivery system
- Chitosan. Chitosan exhibits muco-adhesive properties and can be used to act in the tight epithelial junctions.
- Alginate.
- Xanthan gum.
- Cellulose.
- Liposomes.
- Polymeric micelles.
- Dendrimers.
- Inorganic nanoparticles.
How does magnetic drug delivery work?
Magnetic nanoparticle-based drug delivery is a means in which magnetic particles such as iron oxide nanoparticles are a component of a delivery vehicle for magnetic drug delivery, due to the simplicity with which the particles can be drawn to (external) magnetopuissant targets.
What is targeted drug delivery system?
Targeted drug delivery is a system of specifying the drug moiety directly into its targeted body area (organ, cellular, and subcellular level of specific tissue) to overcome the aspecific toxic effect of conventional drug delivery, thereby reducing the amount of drug required for therapeutic efficacy.
What is meant by drug delivery?
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance.
What is targeted drug delivery used for?
Targeted drug delivery can be used to treat many diseases, such as the cardiovascular diseases and diabetes. However, the most important application of targeted drug delivery is to treat cancerous tumors.
What are targeted drug delivery system?
What are polymeric nanoparticles in drug delivery?
Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system.
What is magnetic drug delivery system?
Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the target area. Up to date there have been many efforts to design the magnet systems for targeted drug delivery. However, there are few comprehensive reviews on these systems.
Why do we need targeted drug delivery?
The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels.