What is the meaning of seronegative spondyloarthropathy?
Seronegative spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases with common clinical and aetiological features, including axial and peripheral inflammatory arthritis, enthesitis, extra-articular manifestations and a close link to the presence of the human leucocyte antigen (HLA)-B27 epitope.
What causes seronegative spondyloarthropathy?
Spondyloarthropathy can develop in association with gastrointestinal conditions (sometimes called enteropathic arthritis) such as inflammatory bowel disease Overview of Inflammatory Bowel Disease Inflammatory bowel disease (IBD), which includes Crohn disease and ulcerative colitis, is a relapsing and remitting …
Is seronegative spondyloarthropathy rheumatoid arthritis?
Spondyloarthropathies are known as seronegative inflammatory disorders, which means they don’t have the same phenotype (cause of auto-immune disorder) as Rheumatoid arthritis.
Is seronegative spondyloarthropathy an autoimmune disease?
A type of autoimmune, inflammatory disease that affects the joints and the etheses resulting in pain, swelling and stiffness.
How is seronegative spondyloarthropathy treated?
Pharmacologic options for SpAs are non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoid injections, and tumor necrosis factor (TNF) inhibitors. NSAIDs are the first line pharmacologic agents in treating SpAs and may have disease modifying activity and reduce radiographic spinal progression of the disease.
Why is it called seronegative?
“Seronegative” refers to the fact that these diseases are negative for rheumatoid factor, indicating a different pathophysiological mechanism of disease than is commonly seen in rheumatoid arthritis.
How common is seronegative spondyloarthropathy?
The worldwide prevalence of SpA is estimated to be between 0.5% to 1.9%[3]. In the United States, AS and non-radiographic axial SpA are the most common types of SpA and have a combined prevalence of 0.7% to 1.4%[2].
What is seronegative polyarthritis?
A seronegative test for rheumatoid arthritis means that a person tests negative for rheumatoid factor (RF) and cyclic citrullinated peptides (CCP).
Is seronegative arthritis the same as rheumatoid arthritis?
The condition affects everyone differently, and symptoms can change over time. But one possible difference is that people who are seropositive commonly get firm lumps on or near their affected joints called rheumatoid arthritis nodules. People who are seronegative generally don’t get these nodules.