What is the meaning of interferon gamma?
: an interferon that is produced by T cells, regulates the immune response, and in a form produced by recombinant DNA technology is used especially to control infections due to inability of white blood cells to destroy certain bacteria and fungi — compare alpha interferon, beta interferon.
What is the Ifng gene?
IFNG (Interferon Gamma) is a Protein Coding gene. Diseases associated with IFNG include Immunodeficiency 69 and Hepatitis C Virus. Among its related pathways are Interferon gamma signaling and Th17 Differentiation.
What is interferon gamma receptor deficiency?
Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease.
Who makes interferon gamma?
IFNγ is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells), macrophages, mucosal epithelial cells and NK cells.
Is interferon gamma a signal molecule?
Although IFN-γ primarily signals through Stat1 homodimers in the initial signal cascade, additional signaling molecules are activated. As noted above, the archetypal type I IFN signaling molecule ISGF3 is activated by IFN-γ, thus providing a mechanism for cross-talk between the types I and II IFN pathways [116].
What produces interferon gamma?
IFNγ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response.
What cells have interferon gamma receptor?
Interferon-gamma is secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells (23–26), γδ T cells (27–33), and natural killer (NK) cells (34, 35) and, to a less extent, by natural killer T cells (NKT), B cells (36–39), and professional antigen-presenting cells ( …
What increases interferon gamma?
It controls genes that are responsible for immune and inflammatory responses and activates macrophages, natural killer cells, and neutrophils [1]. IFN-gamma levels generally increase during infections or immune disorders.
What do interferons do?
The interferons are a family of cytokine mediators critically involved in alerting the cellular immune system to viral infection of host cells.
Where does interferon-gamma come from?
IFNγ is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells), macrophages, mucosal epithelial cells and NK cells. IFNγ is the only Type II interferon and it is serologically distinct from Type I interferons; it is acid-labile, while the type I variants are acid-stable.
What are the effects of interferon gamma polymorphism?
Interactive effects of interferon-gamma functional single nucleotid polymorphism (+874 T/A) with cardiovascular risk factors in coronary heart disease and early myocardial infarction risk. IFN-gamma directly inhibits the activity of erythropoietin in human erythroid progenitors.
Where does interferon gamma inducible gene expression occur?
These phenomena may occur through IFN-gamma expression from the TME. The expression of interferon gamma-inducible genes was high in dermatomyositis, inclusion body myositis, and antisynthetase syndrome but low in immune-mediated necrotizing myopathy.
How is interferon gamma related to cardiovascular disease?
The increased expression of interferon gamma signaling and cholesterol biosynthesis pathways might explain part of the association between APOE4 and cardiovascular disease. Fish-oil supplementation may particularly benefit APOE4 carriers by decreasing expression of interferon gamma related genes.
What is the relationship between interferon gamma and aplastic anemia?
The relationship between interferon-gamma (INF-gamma) single nucleotide polymorphism +874 (T/A) and occurrence risk of aplastic anemia: a meta-analysis. IFN-gamma + 874T/A polymorphism and osteomyelitis.