What is the difference between the cell death PCD program and the necrosis process?
Programmed cell death (PCD; sometimes referred to as cellular suicide) is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. Necrosis is the death of a cell caused by external factors such as trauma or infection and occurs in several different forms.
What are the similarities between apoptosis and necrosis?
Both apoptosis and necrosis require mitochondrial outer membrane damage. Otherwise the known facts are highly in contrast. Is one similarity- cell death in both pathways is induced by this same factors, for example toxins. The dose of toxin is a key, which way of death will be chosen by cell.
Is apoptosis and autophagy?
Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis. Autophagy fulfils this role as it facilitates the degradation of oncogenic molecules, preventing development of cancers, while apoptosis prevents the survival of cancer cells.
How is programmed cell death similar to animal apoptosis?
Programmed cell death in plants has a number of molecular similarities to that of animal apoptosis, but it also has differences, notable ones being the presence of a cell wall and the lack of an immune system that removes the pieces of the dead cell.
How does apoptosis work in the treatment of cancer?
Apoptosis is a multi-step, multi-pathway cell-death programme that is inherent in every cell of the body. In cancer, the apoptosis cell-division ratio is altered. Cancer treatment by chemotherapy and irradiation kills target cells primarily by inducing apoptosis.
What are the postmortem outcomes of apoptosis?
Although it is assumed that all pathogen-induced deaths that have been characterized as apoptosis truly converge on final common pathways that result in equivalent postmortem outcomes, such as apoptotic body removal and inhibition of inflammation, this assumption remains unexplored.
Where does the word apoptosis come from in biology?
Apoptosis (from Ancient Greek ἀπόπτωσις, apóptōsis, “falling off”) is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes ( morphology) and death.