What is structure activity relationship explain?
Structure-Activity Relationship (SAR) is an approach designed to find relationships between chemical structure (or structural-related properties) and biological activity (or target property) of studied compounds.
What spectrum of activity is carbenicillin?
Introduction. Carbenicillin is a semisynthetic, extended-spectrum carboxypenicillin. It is available for oral administration as the indanyl sodium salt. While it is the only extended-spectrum penicillin that is stable in the presence of gastric acids, it is often incompletely absorbed.
What is the structure activity relationship of penicillin?
Penicillin-binding proteins (PBPs) catalyze the essential reactions in the biosynthesis of cell wall peptidoglycan from glycopeptide precursors. beta-Lactam antibiotics normally interfere with this process by reacting covalently with the active site serine to form a stable acyl-enzyme.
How do you find the structure activity relationship?
Structure Activity Relationship is typically evaluated in a table form, called an SAR table. SAR tables consist of the compounds, their physical properties, and activities. Experts review the table by sorting, graphing, and even scanning structural features in order to find possible relationships.
Is carbenicillin broad or narrow spectrum?
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
What is the structure of penicillin?
The basic chemical structure of all penicillins consists of a beta-lactam ring, a thiazolidine ring, and a side chain (6-aminopenicillanic acid). The antibacterial activity of the penicillins lies within the beta-lactam ring.
Which of these drugs has been developed using structure activity relationships?
The correct answer is Atorvastatin.