What is MDM2 amplification?
MDM2 amplification by FISH is designed to detect amplification of the MDM2 gene to aid in patient diagnosis of soft tissue and bone tumors. In soft tissue tumors, MDM2 amplification is a frequent and specific finding in well differentiated liposarcoma/atypical lipomatous tumor (ref.
What does MDM2 positive mean?
A positive result is consistent with amplification of the MDM2 gene locus (12q15) and supports the diagnosis of parosteal osteosarcoma or low-grade central osteosarcoma. A negative result indicates an absence of amplification of the MDM2 gene locus (12q15).
What is an atypical Lipomatous tumor?
Atypical lipomatous tumours are rare tumours which can develop in the soft tissues of the body. This could be in any part of the body, but they are more common in the thigh and arm. They are benign (non-cancerous) tumours but can have a tendency to recur.
What is a well differentiated liposarcoma?
Disease definition. Well-differentiated liposarcoma (WDLS), the most common type of liposarcoma (LS; see this term), is a slow growing, painless tumor usually located in the retroperitoneum or the limbs. It is composed of proliferating mature adipocytes.
What will result from MDM2 amplification?
Therefore, MDM2 can maintain the stability of p53 signaling pathway. MDM2 amplification has been detected in many human malignancies, including lung cancer, colon cancer and other malignancies. MDM2 overexpression is associated with chemotherapeutic resistance in human malignancies.
What is the purpose of MDM2?
Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.
What is Lipomatous?
A lipoma is a slow-growing, fatty lump that’s most often situated between your skin and the underlying muscle layer. A lipoma, which feels doughy and usually isn’t tender, moves readily with slight finger pressure. Lipomas are usually detected in middle age. Some people have more than one lipoma.
What is Lipomatous lesion?
Lipomatous lesions are common musculoskeletal lesions that can arise within the soft tissues, bone, neurovascular structures, and synovium. The majority of these lesions are benign, and many of the benign lesions can be diagnosed by radiologic evaluation.
Can liposarcoma be cured?
What are liposarcoma treatment options? The treatment of liposarcoma is mainly surgical, with the goal to remove the tumor entirely and prevent its recurrence (achieving a cure) by removing all of the tumor cells. In the past, amputation was the surgical option for these tumors in the limbs.
What are the two roles of MDM2?
In this classic model, MDM2 directed p53 ubiquitination and degradation play the central role. However, emerging evidence suggests dual roles of MDM2 as a repressor of p53 activity. Ubiquitination dependent and ubiquitination independent mechanisms are jointly present to control p53 activity.