What is isosorbide mononitrate 60 mg used for?
Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.
What does isosorbide do for the heart?
ISOSORBIDE MONONITRATE (eye soe SOR bide mon oh NYE trate) is a vasodilator. It relaxes blood vessels, increasing the blood and oxygen supply to your heart. This medicine is used to prevent chest pain caused by angina. It will not help to stop an episode of chest pain.
What are the side effects of isosorbide?
COMMON side effects
- low blood pressure.
- dizziness.
- temporary redness of face and neck.
- headache.
- nervousness.
- a feeling of pins and needles on skin.
How many mg of isosorbide mononitrate is in a tablet?
Isosorbide Mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Each Isosorbide mononitrate extended-release tablet, for oral administration contains 30 mg, 60 mg or 120 mg of ISMN.
Which is better isosorbide 60 mg or 120 mg?
Isosorbide mononitrate extended-release tablets during long-term use over 42 days dosed at 120 mg once daily continued to improve exercise performance at 4 hours and at 12 hours after dosing but their effects (although better than placebo) are less than or, at best, equal to the effects of the first dose of 60 mg.
Why is isosorbide mononitrate used for angina pectoris?
Isosorbide mononitrate is indicated for the prevention and management of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid to be useful in aborting an acute anginal episode.
How long does it take for isosorbide mononitrate to reach Cmax?
Isosorbide mononitrate has a dose-linear kinetics and the absolute bioavailability is nearly 100%. The Cmax is reached within 30 to 60 minutes following administration. In a human radio-labelled drug study, about 93% of the total dose was excreted in the urine within 48 hours.