What is contraindication for use of procainamide?
The use of procainamide is contraindicated in patients with torsade de pointes as procainamide can actually aggravate this arrhythmia instead of suppressing it. Similarly, procainamide should be avoided when possible in patients with QT prolongation due to the increased risk of proarrhythmic effects.
When should you not use procainamide?
Who should not take?
- high levels of potassium in the blood.
- low amount of potassium in the blood.
- decreased blood platelets.
- very low levels of granulocytes, a type of white blood cell.
- myasthenia gravis, a skeletal muscle disorder.
- heart attack within the last 30 days.
- complete heart block.
Why is procainamide contraindicated in CHF?
Procainamide should not be administered to patients with complete heart block because of its effects in suppressing nodal or ventricular pacemakers and the hazard of asystole.
Is procainamide contraindicated in pregnancy?
Procainamide (PA) has been used safely in the third trimester of pregnancy for the treatment of ventricular tachycardia. PA crosses the human placenta. There are no reports of congenital anomalies or adverse fetal effects associated with the use of procainamide during human pregnancy.
How is procainamide toxicity treated?
In overdose, charcoal can be considered after securing the airway but the mainstay treatment for toxicity is treatment of underlying rhythms using sodium bicarbonate, magnesium, and overdrive pacing. In chronic toxicity, procainamide has been linked to a drug-induced systemic lupus erythematosus syndrome.
Is procainamide contraindicated in heart failure?
Although blockers are important antiarrhythmic drugs in patients with HF, other antiarrhythmic drug therapies have been disappointing. The class I sodium channel-blocking drugs (mexiletine, tocainide, procainamide, quinidine, disopyramide, flecainide, and propafenone) should be avoided.
Can procainamide cause fever?
Your doctor will order certain lab tests to check your response to procainamide. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, bruising, bleeding, muscle aches or weakness, stomach or chest pain, skin rash, or blisters on the cheek, tongue and lips.
How is procainamide metabolized?
Procainamide is eliminated by hepatic metabolism and renal excretion. It is metabolized to N-acetyl procainamide (NAPA), by conjugation by N-acetyl transferase.