What is ABCB1 transporter?
The ATP-binding cassette (ABC) transporter protein ABCB1 (P-glycoprotein) is known for its involvement in multidrug resistance (MDR) of tumor cells by preventing intracellular accumulation of cytotoxic drugs.
Where is ABCB1 located?
The ABCB1 gene, encoding the P-glycoprotein, is located on chromosome 7q21. 1, consists of 28 introns and 28 exons. ABCB1 mRNA is 4.7 kb and is contained in the coding region of 120 kb. The ABCB1 gene has been extensively studied for characteristic polymorphisms and about 50 SNPs for ABCB1 have been identified7.
Where is ABCB1 found?
How common is MDR1 in dogs?
The MDR1 mutation has been identified in 10 herding breeds, 2 sighthound breeds, and herding-breed mixed dogs (TABLE 1). Collies have one of the highest frequencies—approximately 70% are homozygous or heterozygous for the mutation….A Herding Dog Gene.
| BREED | APPROXIMATE FREQUENCY (%) |
|---|---|
| Border collie | <5 |
What kind of transporter is P-gp?
P-glycoprotein
Pgp (P-glycoprotein) (ABCB1) is an ATP-powered efflux pump which can transport hundreds of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs, peptides and lipid-like compounds.
What drugs are P-gp inhibitors?
Some common pharmacological inhibitors of P-glycoprotein include: amiodarone, clarithromycin, ciclosporin, colchicine, diltiazem, erythromycin, felodipine, ketoconazole, lansoprazole, omeprazole and other proton-pump inhibitors, nifedipine, paroxetine, reserpine, saquinavir, sertraline, quinidine, tamoxifen, verapamil.
How many ABC transporters are there?
There are 48 ABC transporters in humans [8,9] and many of these have been shown to be responsible for or involved in disease states, including cystic fibrosis, Tangier disease, adrenoleukodystrophy, and cancer (see below).
How is ABCB1 c.3435c > T related to platinum?
The present study reveals that ABCB1 c.3435C>T polymorphism influences platinum toxicity. The T allele seems to exert a protective effect on the development of toxicities. Further studies, such as epigenetic regulation ones, are needed to validate and shed more light on this association.
What are the effects of the ABCB1 C3435T polymorphism?
Effects of the ABCB1 C3435T single nucleotide polymorphism on major adverse cardiovascular events in acute coronary syndrome or coronary artery disease patients undergoing percutaneous coronary intervention and treated with clopidogrel: A systematic review and meta-analysis.
How does ABCB1 and ABCG2 inhibit multiple transporters?
ABCB1 and ABCG2 can independently and additively confer resistance to substrates, underscoring the need to inhibit multiple transporters when they are coexpressed
How are ABCB1 and Klf4 related to paclitaxel resistance?
Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4. Differential expression of ABCB1, ABCG2, and KLF4 as putative indicators for paclitaxel resistance in human epithelial type 2 cells.