What is a high viral load for HCV?
High viral load: This is when your count is more than 800,000 IU/mL. If your viral count is high at the start, it can be hard or impossible for your treatment to completely get rid of the virus. Some researchers consider high levels anything above 400,000 IU/mL.
What is high HCV?
A viral load of more than 800,000 IU/mL is considered high. This can make successful treatment more challenging. Undetectable viral load. A viral load of less than 615 IU/mL means there’s no detectable HCV, or it’s too low to detect.
What is a high level of HCV RNA?
The quantitative HCV RNA test is checked before a patient starts treatment. For each patient, the result can be described as either a “high” viral load, which is usually >800,000 IU/L, or a “low” viral load, which is usually <800,000 IU/L. It’s not uncommon to have a viral load in the millions.
What is HCV RNA positive?
A positive test might occur when a person has had a previous HCV infection. This may mean that a person still has antibodies, but the body has already cleared the infection. This happens in about 15–25% of tests. The virus is more likely to clear in people whose symptoms develop in the early phase of the infection.
How is the replication of HCV dependent on miR-122?
Recent studies have shown that replication of hepatitis C virus (HCV) is dependent on miR-122 expression. miR-122 regulates HCV by binding directly to two adjacent sites close to the 5′ end of HCV RNA.
How is Mir 122 related to hepatocellular carcinoma?
Reduced miR-122 levels are associated with hepatocellular carcinoma. miR-122 also plays an important positive role in the regulation of hepatitis C virus replication. miR-122 was originally identified by cloning of tissue-specific microRNAs in mouse, where its expression is restricted to the liver.
How is HuR interaction related to miR-122?
The HuR interaction leads to release of the mRNA from the P bodies and resumption of active translation. A number of other miR-122 targets, including CD320, AldoA and BCKDK, have been identified by microarray analysis of changes in mRNA expression in the liver of mice treated with miR-122 inhibitors.
Where is miR-122 located in chromosome 18?
In humans, miR-122 is encoded at a single genomic locus in chromosome 18. The primary miR-122 transcript (pri-miR-122) is a long non-coding RNA. Transcription is regulated by HNF4α. The miR-122 hairpin precursor consensus shown here is predicted based on base pairing and cross-species conservation.