What does MANEC mean?
Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon.
WHO classification of appendiceal neuroendocrine tumors?
According to the current WHO classification[3], appendiceal NETs are classified as: (1a) Well differentiated NETs with benign biological behaviour or (1b) Well differentiated NETs with uncertain malignant potential; (2) Well differentiated neuroendocrine carcinoma (with low malignant potential); and (3) Mixed exocrine- …
What happened Madame Manec?
Etienne refuses at first, but after Madame Manec dies of pneumonia, her plan becomes a reality.
Who is Madame Manec in All the Light We Cannot See?
Madame Manec is very brave and creative, and even though she does not have a lot of power, she uses all her resources and inventiveness to resist the German occupation. She has a leadership position among the other townspeople, and this allows her to make the resistance movement more influential.
What is neuroendocrine cell?
Neuroendocrine cells are like nerve cells ( neurons. Close. neuron. A specialized cell that sends and receives messages (electrical or chemical signals) within the nervous system.
What kind of carcinoid is a Manec tumor?
WHO 2010 appears in places to sugggest that the term MANEC includes tumors in which the neuroendocrine component is a low grade neuroendocrine tumor (carcinoid) as well as including carcinoma ex-goblet cell carcinoid
How is the appendiceal Manec used in medicine?
With the non-MANEC histologies being appendiceal only, the appendiceal MANEC ( n = 249) were used for clinicopathological and survival comparisons. The data were retrospectively reviewed, and demographics, clinicopathological characteristics, treatment regimens, and survival data were obtained.
Which is more aggressive Manec or GCC of the appendix?
MANEC is a more aggressive clinical entity than both GCC of the appendix and carcinoid/neuroendocrine tumors of the appendix. Based on these findings, we recommend patients with MANEC tumors undergo aggressive multidisciplinary cancer management and close surveillance. Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity
Is there such a thing as a Manec?
MANEC as used in the literature refers only to the association of differentiated adenocarcinoma and high grade neuroendocrine carcinoma Carcinoma ex-goblet cell carcinoid is a distinict clinicopathologic entity which has not in the past been referred to as MANEC