What does LIN28 do?
LIN28 encodes an RNA-binding protein that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA. Lin28 binds to the let-7 pre-microRNA and blocks production of the mature let-7 microRNA in mouse embryonic stem cells.
What is LIN protein?
About LIN Protein: LIN28 encodes an RNA-binding protein, which binds to and promotes translation of the IGF-2 (insulin-like growth factor 2) mRNA. LIN protein is found in ribosomes, P-bodies, and stress granules in pluripotent embryonal carcinoma cells.
How does Lin28 let 7 control development and disease?
Lin28 is a stem cell pluripotency factor During embryonic development Lin28 levels decline allowing an accumulation of let-7 miRNAs. let-7 induction inhibits the self-renewal of undifferentiated cells and promotes differentiation.
What is lineage negative?
Lineage Negative (Lin-) Markers Note A select list of Lin- markers are provided as examples of markers that have been used in the literature to exclude particular lineages of cells in order to help identify the cell type of interest.
Is LIN28A real?
LIN28A (Lin-28 Homolog A) is a Protein Coding gene. Diseases associated with LIN28A include Embryonal Tumor With Multilayered Rosettes and Central Nervous System Primitive Neuroectodermal Neoplasm. Among its related pathways are Developmental Biology and Translational Control.
What is a lineage cocktail?
The Lineage-PE Cocktail is comprised of PE-conjugated CD3, CD14, CD19, CD20 and CD56 antibodies. It enables the positive staining of five immune cell populations (T and B Lymphocytes, NK cells, Monocytes/Macrophages) together, without distinction, in the PE channel using flow cytometry.
What is Lin in bone marrow?
Literature. Lin- cells are bone marrow derived lineage-negative cells that are negatively selected by several antibodies for lymphocytes, macrophages, granulocytes and erythrocytes.
What is SOX2 genetic disorder?
SOX2 anophthalmia syndrome is a rare disorder characterized by abnormal development of the eyes and other parts of the body. People with SOX2 anophthalmia syndrome are usually born without eyeballs (anophthalmia), although some individuals have small eyes (microphthalmia).
What is the difference between totipotency and pluripotency?
Pluripotent stem cells are formed from totipotent stem cells when their differentiation potential is reduced….Differentiate between totipotent and pluripotent cells.
| Characteristics | Totipotent cells | Pluripotent cells |
|---|---|---|
| Examples | Spore and zygote are totipotent. | Embryonic stem cells and iPS are pluripotent. |