What does JNK stand for?
JNK
| Acronym | Definition |
|---|---|
| JNK | Jun N-terminal Kinase |
| JNK | Junk (File Name Extension) |
| JNK | Jun Nuclear Kinase |
What is Erk in biology?
The extracellular-signal-regulated kinase (ERK) pathway is one of the major signaling cassettes of the mitogen activated protein kinase (MAPK) signaling pathway. One of the major transcription factors is cyclic AMP response element-binding protein (CREB).
What is p38 biology?
p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.
Is STAT3 a transcription factor?
STAT3 belongs to the signal transducer and activator of transcription (STAT) family of signal responsive transcription factors which consists of seven members encoded by distinct genes.
Why is the JNK pathway important to the CNS?
The JNK pathway has a diverse functionality and cell-tissue specificity, and has emerged as a key player in regeneration, tumorigenesis and other pathologies. The JNK pathway is highly active in the central nervous system (CNS), and plays a central role when cells need to cope with pathophysiological insults during development and adulthood.
What is the role of c-Jun N-terminal kinase ( JNK )?
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration, cell death, and regulation of cellular senescence. It has been shown that there is a JNK pathway activation after exposure to different stressing factors,
Where is the JNK pathway found in mammals?
In mammals, the JNK pathway is encoded by jnk1, jnk2and jnk3[20]. JNK1 and JNK2 are found ubiquitously, whereas JNK3 is restricted to the brain, cardiac smooth muscle and testis [20,21]. In particular, the JNK pathway is highly active in the CNS as compared with other tissues.
How is the JNK pathway initiated in Drosophila?
In Drosophila,JNK pathway-signalling is initiated by the interaction of the ligand protein Eiger (Egr), the unique TNF superfamily member of ligands [12,13], with TNF receptors (TNFRs) Grindewal (Grnd) [14], or Wengen (Wng) [15]. Ligand–receptor interaction initiates a cascade of phosphorylations that mediates the JNK signalling pathway [11].