What defines high throughput and high content screens?
High Throughput Screening (HTS) is a technique to sort useful compounds quickly and efficiently from a huge number of candidates for new drugs. High-Content Screening (HCS) is an imaging-based multi-parametric analysis method that is used in biological research and drug discoveries.
What is high throughput screening used for?
High-throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization.
What is high content image analysis?
High content imaging applies automated microscopy, fluorescent detection, and multiparameter algorithms to visualize and quantify the interaction of therapeutics in cell populations.
What is the screening of cells?
Cell screening or, in other words, identification of cells with certain properties is now increasingly used in scientific and medical research, e.g., in diagnostics, drug testing, and production of cell clones with desired characteristics.
What is high throughput screening Slideshare?
HIGH THROUGHPUT SCREENING (HTS) is identification of one or more positive candidates extracted from a pool of possible candidates based on specific criteria It is a drug-discovery process widely used in the pharmaceutical industry It allows automation to quickly assay the biological or biochemical activity of a …
What is meant by high throughput?
Quick Reference. Describing a process that is scaled up, usually via increased levels of automation using robots.
What are high throughput screening methods?
High-throughput screening (HTS) is a drug discovery process that allows automated testing of large numbers of chemical and/or biological compounds for a specific biological target.
What is the meaning of high throughput?
How does high content screening work?
In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells are analyzed. The most common analysis involves labeling proteins with fluorescent tags, and finally changes in cell phenotype are measured using automated image analysis.
What is a high throughput lab?
Definition. High throughput screening (HTS) is the use of automated equipment to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level.
What is high throughput screening PPT?