What causes high levels of neutrophils in blood?
A high neutrophil count may be due to many physiological conditions and diseases. In most cases, high neutrophils count is commonly associated with an active bacterial infection in the body. In rare cases, the high neutrophil count may also result from blood cancer or leukemia.
What is Hyperleukocytosis?
INTRODUCTION. Hyperleukocytosis refers to a laboratory abnormality that has been variably defined as a total leukemia blood cell count greater than 50 x 109/L (50,000/microL) or 100 x 109/L (100,000/microL).
Which is the most common etiology of hyperleukocytosis?
Hyperleukocytosis is defined as peripheral blood leukocyte count exceeding 100,000/mm(3). Acute leukemia is the most common etiology in pediatric practice. Hyperleukocytosis is a medical emergency. The increased blood viscosity, secondary to high white cell count and leukocyte aggregates, results in …
Why is hyperleukocytosis a high morbidity index?
Hyperleukocytosis has a high morbidity index. The involvement of the respiratory or central nervous system and the metabolic derangements accompanying tumor lysis are responsible for early mortality. Standard care for acute hyperleukocytosis must include cytoreduction, proper supportive care, and pr …
Can a red cell transfusion be used for hyperleukocytosis?
A red cell transfusion is not indicated in a hemodynamically stable child, as it adversely affects the blood viscosity. Leukapheresis is the treatment of choice for a very high count, or in patients with symptomatic hyperleukocytosis.
What is the normal WBC count for leukocytosis?
Leukocytosis is the broad term for an elevated white blood cell (WBC) count, typically above 11.0×10^9/L, on a peripheral blood smear collection. The exact value of WBC elevation can vary slightly between laboratories depending on their ‘upper limits of normal’ as identified by their reference ranges.