What are the metabolites of Xanax?
Metabolism/Elimination Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam and α hydroxyalprazolam. A benzophenone derived from alprazolam is also found in humans.
What drug is alprazolam metabolite?
Alprazolam is detected as the metabolite α-hydroxyalprazolam. Clonazepam is detected as the metabolite 7-aminoclonazepam.
Where is Xanax metabolized?
Alprazolam is metabolized by the liver via the cytochrome P450 system, predominantly by CYP 3A4. Concurrent use of CYP 3A4 inhibitors, such as cimetidine or ketaconazole, can cause an increase in alprazolam plasma levels.
What are the metabolites of lorazepam?
Metabolites present were lorazepam glucuronide, a quinazolinone, a quinazoline carboxylic acid, and two hydroxylorazepam isomers, one of which is novel, having the hydroxyl group located on the fused chlorobenzene ring.
What is alpha hydroxy midazolam?
α-Hydroxymidazolam a-Hydroxymidazolam is an active, major metabolite in urine and blood of the benzodiazepine, midazolam. Midazolam is sold as Dormicum, Hypnovel, and Versed as a sedative and treatment for insomnia and seizures.
What is the strongest benzodiazepine on the market?
Alprazolam is the only high-potency benzodiazepine developed in an XR formulation.
Does Xanax raise liver enzymes?
Some people experience elevated liver enzymes when using Xanax long-term. This may be a sign of liver inflammation, a condition that can lead to or result from damage to liver tissue. Liver damage is even more likely if Xanax is combined with alcohol.
What do you need to know about Xanax metabolization?
Before going into the specifics of where Xanax is metabolized, the following is a brief overview of the drug. Xanax is part of a class of medicines called benzodiazepines. These drugs are intended for the treatment of anxiety primarily, as well as panic disorders, and in some cases insomnia, and treatment for withdrawal from alcohol.
What is the chemical formula for Xanax tablet alprazolam?
XANAX Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4] benzodiazepine. The structural formula is represented to the right:
What is the half life of Xanax XR tablet?
Alprazolam and its metabolites are excreted primarily in the urine. The mean plasma elimination half-life of alprazolam following administration of XANAX XR Tablet ranges from 10.7–15.8 hours in healthy adults.
Where does Xanax show up on a drug test?
For example, if you are a bigger person with a high percentage of body fat and you take Xanax regularly, you are likely to have some of the drug stored in your fat cells, and it could show up on a drug test such as a urinalysis for an extended period of time.