Is Src a membrane protein?
Cellular c-Src (Src) is a nonreceptor protein tyrosine kinase associated with the plasma membrane, cell–matrix and cell–cell adhesions, and endosomal vesicles.
What is Src in signaling pathway?
Src is a non-receptor cytoplasmic tyrosine kinase which becomes activated following the stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins, and is an indispensable player of multiple physiological homeostatic pathways.
What does the Src protein do?
Src is a non-receptor protein tyrosine kinase that transduces signals that are involved in the control of a variety of cellular processes such as proliferation, differentiation, motility, and adhesion.
How is Src protein activated?
First, Src can be activated by receptor tyrosine kinases such as EGFR and HGF receptor (Maa et al., 1995; Mao et al., 1997). These receptors have been known to be active in the progression of cancer, and, in turn, may activate Src.
What type of kinase is Src?
receptor tyrosine kinases
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.
How does Src get activated?
How do I activate my Src?
Where is Src protein located?
Proto-oncogene tyrosine-protein kinase Src
| SRC | ||
|---|---|---|
| Location (UCSC) | Chr 20: 37.34 – 37.41 Mb | Chr 2: 157.42 – 157.47 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
What type of protein is Src?
non-receptor tyrosine kinase protein
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced “sarc”, as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.
What is the Src gene family?
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.