Is benzofuran aromatic?
Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.
Which one is the example of benzofuran derivative?
This colourless liquid is a component of coal tar. Benzofuran is the “parent” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants….Benzofuran.
| Names | |
|---|---|
| ECHA InfoCard | 100.005.439 |
| EC Number | 205-982-6 |
| Gmelin Reference | 260881 |
| KEGG | C14512 |
What is benzofuran derivatives?
Benzofuran derivatives are an important heterocyclic compounds that are possess vital biological activities such as antidepressant, anticancer, antiviral, antifungal, antioxidant, anti-psychotic etc. Benzofurans presents in various natural products with various physiological, pharmacological and toxic properties.
What is benzofuran used for?
Benzofuran compounds are a class of compounds that are ubiquitous in nature. Numerous studies have shown that most benzofuran compounds have strong biological activities such as anti-tumor, antibacterial, anti-oxidative, and anti-viral activities.
Is benzofuran soluble in water?
Very slightly water soluble.
Is benzofuran planar?
By inside fusion with benzofuran, two molecules exhibit high-lying LUMO energy levels and a totally planar molecular backbone.
Which antiarrhythmic drug is benzofuran derivative and having iodine in side chain?
Amiodarone, an iodinated benzofuran derivative, was approved in the United States in 1985 for the treatment of life-threatening ventricular tachyarrhythmias [16].
Is benzofuran toxic?
Benzofuran as a Recreational Drug Bromo-dragonFLY, for example, has caused toxicity in the body that has led to limbs being amputated. Deaths related to benzofuran use have also been reported in the US and Europe.
Why benzofuran is more stable than furan towards acid?
Why benzofuran is more stable than furan towards acid? Solution. But benzofuran is more resistant to acid than furan, since there is an additional benzene ring in the benzofuran, the presence of which leads to stabilization of the resonant structure, due to the redistribution of the electron density in the benzofuran.
Where is pyrrole found?
The pyrrole ring system is present in the amino acids proline and hydroxyproline; and in coloured natural products, such as chlorophyll, heme (a part of hemoglobin), and the bile pigments. Pyrrole compounds also are found among the alkaloids, a large class of alkaline organic nitrogen compounds produced by plants.
Is the benzene ring in benzofuran colorless?
Benzofuran is one of the most important fused heterocycles, containing a benzene ring fused to a furan ring. Benzofuran itself is a colorless liquid obtained from coal tar. Its derivatives are the scaffold of many natural products and several complex structures.
Are there any natural or synthetic compounds that contain benzofuran?
Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals [66]. Many methods have been developed for the synthesis of benzofuran in homogeneous and heterogeneous catalytic pathway.
How is benzofuran bonded to a MN fragment?
Benzofuran bonded to an Mn (CO)3 fragment undergoes C–O bond activation by a Pt (0)–PPh3 complex to yield a six-membered 2-oxa-platinacycle 429 (Scheme 60). Daryl S. Walter, in Comprehensive Organic Functional Group Transformations, 1995 Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions.
How is benzofuran prepared at the 2 position?
Benzofuran is lithiated selectively at the 2-position using alkyllithium reagents, and 3-lithio derivatives (although thermally unstable) can be prepared by halogen–metal exchange. However, the application of such methodology to the direct synthesis of ketone derivatives is conspicuously lacking.