How much does Kcentra cost?
Intravenous Powder For Injection
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $12.34 | $12.34 |
How long does it take for Kcentra to work?
Effective hemostasis measured up to 24 hours for the Acute Major Bleeding trial and until the end of procedure (up to 24 hours) for the Urgent Surgery/Invasive Procedures trial. Rapid INR reduction to ≤1.3 at 0.5 hours after end of infusion.
Can Kcentra be repeated?
In general, a single dose is given; dosing may be repeated in rare situations in which the oral anticoagulant persists for longer in the circulation, such as severe kidney dysfunction.
How is Kcentra calculated?
A single dose of Kcentra is determined by the patient’s pretreatment INR and weight. *Dosing is based on body weight. Dose based on actual potency is stated on the vial, which will vary from 20–31 Factor IX units/mL after reconstitution. The actual potency for 500 unit vial ranges from 400–620 units/vial.
Is Kcentra a blood product?
Because Kcentra is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease agent. There is also the possibility that unknown infectious agents may be present in such products.
Is Kcentra FDA approved?
The U.S. Food and Drug Administration (FDA) announced its approval of Kcentra (Prothrombin Complex Concentrate) on April 30. The drug, a first-in-class therapy, is used for urgent vitamin K antagonist (VKA) anticoagulation reversal in adult patients with acute major bleeding.
How long does Kcentra affect INR?
Monitor INR and clinical response during and after treatment. In clinical trials, Kcentra decreased the INR to ≤1.3 within 30 minutes in most subjects. The relationship between this or other INR values and clinical hemostasis in patients has not been established [see Clinical Studies (14)].
When can I check INR after Kcentra?
- Recheck INR 30 minutes after Kcentra® dose. Kcentra®=4-Factor PCC.
- Time elapsed: Immediate. Protamine 1–1.5 mg slow IV.
- Time elapsed: 30 – 60 minutes. Protamine 0.5–0.75 mg slow IV.
- Time elapsed: >2 hours. Protamine 0.25– 0.375 mg slow IV.
- Enoxaparin (Lovenox ®)
- 0.5 mg Protamine per.
- Time elapsed: < 8 hours.
What is the INR of Kcentra?
In clinical trials, Kcentra decreased the INR to ≤1.3 within 30 minutes in most subjects. The relationship between this or other INR values and clinical hemostasis in patients has not been established [see Clinical Studies (14)].
What is Kcentra medication?
Kcentra, (Prothrombin Complex Concentrate (Human)), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.
What is Kcentra the antidote for?
What is Kcentra? Kcentra (prothrombin complex) is a blood coagulation factor replacement product. Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.