How do you administer prothrombin complex concentrate?
Dosing of prothrombin complex concentrate should be based on the INR as per the table below. If the INR is unknown and maor bleeding is present 80 mL should be administered. Administration: Must be administered intravenously. May be administered by direct IV push, syringe pump or minibag.
What lab value is required for dosing of Kcentra?
Administer Kcentra: By intravenous infusion at a rate of 0.12 mL/kg/min (~3 units/kg/min) up to a maximum rate of 8.4 mL/min. Concurrently with vitamin K.
What is 4 factor prothrombin complex concentrate?
The 4-factor prothrombin complex concentrate (4F-PCC), which contains the human coagulation factors II, VII, IX and X together with the endogenous inhibitor proteins S and C, is indicated for the urgent reversal of acquired coagulation factor deficiency induced by VKA (e.g. warfarin or coumarin) therapy in adult …
Should vitamin K be given with Kcentra?
Administer Vitamin K concurrently to patients receiving Kcentra. Vitamin K is administered to maintain Vitamin K-dependent clotting factor levels once the effects of Kcentra have diminished. The safety and effectiveness of repeat dosing have not been established and it is not recommended.
How much PCC should I give?
1. Give 3F PCC* 1500 to 2000 units¶ IV over 10 minutes. Check INR 15 minutes after completion of the infusion. If INR is not ≤1.5, give additional 3F PCC (refer to topic or drug reference for details).
When is prothrombin complex concentrate given?
Prothrombin complex concentrate reverses the effects of warfarin and other vitamin K antagonist anti-coagulants and is used in cases of significant bleeding in people with a coagulopathy. It is also used when such a person must undergo an emergency operation treatment.
How concentrated is Kcentra over plasma?
Kcentra uses less volume and is more concentrated than plasma. Kcentra requires ~85% less volume and is ~25x more concentrated than plasma. *Mean infusion volume was 90 mL (±32 mL) for Kcentra and 819 mL (±231 mL) for plasma.
How long does prothrombin complex concentrate last?
Data on PCC pharmacokinetics are scant. The half-lives of the four clotting factors differ widely. The half-life of FII is much longer (60–72 h) than that of the other factors (6–24 h). FVII has the shortest half-life (approximately 6 h)4.
When do you take vitamin K and Kcentra?
Administer vitamin K concurrently to patients receiving Kcentra. Vitamin K is administered to maintain vitamin K–dependent clotting factor levels once the effects of Kcentra have diminished.