Does ITP cause splenomegaly?
ITP is a primary illness occurring in an otherwise healthy person. Signs of chronic disease, infection, wasting, or poor nutrition indicate that the patient has another illness. Splenomegaly excludes the diagnosis of ITP.
Which of the following is a characteristic of acute idiopathic thrombocytopenic purpura?
Idiopathic thrombocytopenic purpura is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood. A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding. ITP may be acute and resolve in less than 6 months, or chronic and last longer than 6 months.
Why does splenectomy help ITP?
Why remove the spleen? In people with ITP the immune system treats platelets as foreign and destroys them. The spleen is responsible for removing these damaged platelets and therefore removal of the spleen can help to keep more platelets circulating in the body.
Why does splenomegaly cause leukopenia?
Anemia – The anemia observed in splenomegaly results from sequestration and hemodilution. Leukopenia – Increased destruction or sequestration of leukocytes causes the leukopenia observed in splenomegaly.
Does splenomegaly cause low platelets?
If a condition causes the spleen to enlarge (splenomegaly), the spleen will function abnormally, sequestering up to 90% of the total platelet mass in the spleen. The result is a decrease in circulating platelets (thrombocytopenia).
How is TTP diagnosed?
Your doctor will diagnosis thrombotic thrombocytopenic purpura (TTP) based on your medical history, a physical exam, and test results. If TTP is suspected or diagnosed, a hematologist will be involved in your care. A hematologist is a doctor who specializes in diagnosing and treating blood disorders.
What platelet count is thrombocytopenia?
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia. You get your platelet number from a routine blood test called a complete blood count (CBC).
What are the symptoms of idiopathic thrombocytopenic purpura?
What are the symptoms of idiopathic thrombocytopenic purpura? Normal platelet count is in the range of 150,000 to 450,000. With ITP, the platelet count is less than 100,000. By the time significant bleeding occurs, you may have a platelet count of less than 10,000.
How are platelets used to treat immune thrombocytopenic purpura?
Immune thrombocytopenic purpura. Refractory ITP (not responsive to conventional treatment) may require splenectomy, the surgical removal of the spleen. Platelet transfusions may be used in severe bleeding together with a very low count. Sometimes the body may compensate by making abnormally large platelets.
What’s the difference between ITP and thrombocytopenia?
Thrombocytopenia means a decreased number of platelets in the blood. Purpura refers to the purple discoloring of the skin, as with a bruise. ITP is a fairly common blood disorder that both children and adults can develop. There are two forms of ITP:
Can a spleen be enlarged to cause thrombocytopenia?
Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia. Bleeding time is usually prolonged in ITP patients.