What is the function of CCL3?
Function. CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.
What is mip1?
Abstract. Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis.
Where is mip1?
MIP-1α/CCL3 is a multifunction peptide that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation. MIP-1α/CCL3-expressing cells are usually found in areas of inflammation and bone resorption. MIP-1α/CCL3 recruits macrophages, lymphocytes, and eosinophils via the CCR1 or CCR5 receptor.
Is macrophage a protein?
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines….Macrophage inflammatory protein.
| chemokine (C-C motif) ligand 4 | |
|---|---|
| Alt. symbols | SCYA4, MIP-1β, LAG1 |
| NCBI gene | 6351 |
| HGNC | 10630 |
| OMIM | 182284 |
What is the structure of CCl3?
Trichloromethanide
| PubChem CID | 119237 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | CCl3- |
| Synonyms | trichloromethanide Methane, trichloro-, ion(1-) 14478-07-0 Trichloromethane ion(1-) DTXSID70162801 |
| Molecular Weight | 118.37 |
What is the bond angle of CCl3?
In both CCl3−CF2Cl and Cl3C−CCl3 cases the C−C bonds lie in the (0k0) plane, the molecules being alternatively tilted with respect to the [00l] direction by an angle of 7.0° (at 125 K) and 6.7° (at 5 K) in CCl3−CF2Cl and 13.2° in C2Cl6 (at 10 K).
Is IL 6 a proinflammatory?
IL-6 exhibits two contrasting features. In models of chronic inflammatory diseases, such as collagen-induced arthritis, murine colitis, or experimental autoimmune encephalomyelitis, IL-6 is proinflammatory [28,29], whereas in models of acute inflammation IL-6 exhibits an anti-inflammatory profile [10].
What is rantes in immunology?
RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry.
Which protein is produced by macrophages?
CXCL1 and CXCL2 (also known as macrophage inflammatory protein 2-α, MIP) share 90% amino acid similarity and are secreted by monocytes and macrophages to recruit neutrophils and hematopoietic stem cells (72, 73).
What is the chemical name of CCl3?
Trichloromethyl radical
Trichloromethyl radical
| PubChem CID | 122980 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | CCl3 |
| Synonyms | Trichloromethyl radical Trichloromethyl free radical Trichloromethyl 3170-80-7 Methyl, trichloro- More… |
| Molecular Weight | 118.37 |
What is the hybridization of CCl3?
The compound CCL3 does not exist ,it should be CCL4 its name is carbon tetrachloride . Its arrangement is tetrahedral. Its hybridisation is sp3.
Is CCl3 polar or nonpolar?
Is the ccl3 molecule polar or nonpolar? the molecule is nonpolar.
What is the role of MIP-1 alpha null mice?
However, the MIP-1 alpha null mice have a mice have a reduced inflammatory reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses.
Where does the inflammatory protein MIP-3 come from?
It is produced mainly by macrophages, monocytes and epithelial cells and is responsible for chemotaxis to the source of inflammation and activation of neutrophils. There are two chemokines in the MIP-3 group.
What is the role of MIP-1 in homeostasis?
MIP-1 are best known for their chemotactic and proinflammatory effects but can also promote homeostasis. Biophysical analyses and mathematical modelling has shown that MIP-1 reversibly forms a polydisperse distribution of rod-shaped polymers in solution. Polymerization buries receptor-binding sites of MIP-1,…
Is the MIP-1 alpha gene necessary for hematopoiesis?
Here, the biologic properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis.