What is Morphea?
Morphea is an autoimmune disease that causes sclerosis, or scarlike, changes to the skin. Autoimmune diseases occur when the immune system, which normally protects us from bacteria, viruses, and fungi, mistakenly attacks a person’s own body.
What are the two types of scleroderma?
There are two main categories of scleroderma: localized and systemic. Each category is made up of several conditions. Localized scleroderma: often affects only the skin and not major organs.
What kind of disease is scleroderma?
Scleroderma is believed to be an autoimmune disease. This means that it occurs in part because the body’s immune system begins to attack the connective tissues.
What does SCL 70 indicate?
Serum anti-topoisomerase, also known as SCL-70, is specific to diffuse scleroderma (and the test is positive in 20% of people with scleroderma). Two-thirds of patients with this antibody have diffuse scleroderma. They also have pulmonary interstitial fibrosis and reduced survival.
What is the ICD 10 code for localized Dermatosclerosis?
L94.0
L94. 0 – Localized scleroderma [morphea]. ICD-10-CM.
What’s the difference between scleroderma and morphea?
Scleroderma is a disease of unknown origin that affects the microvasculature and loose connective tissues of the body and is characterized by fibrosis and obliteration of vessels in the skin, lungs, gut, kidneys and heart. Morphea is a localized form of scleroderma and affects primarily just the skin.
Can Scl 70 be a false positive?
Scl-70 (topo-1) is a DNA binding protein and anti-DNA/DNA complexes in the sera of SLE patients may bind to topo-I, leading to a false-positive result. The presence of Scl-70 antibody in sera may also be due to contamination of recombinant Scl-70 with DNA derived from cellular material used in immunoassays.
Does everyone have Scl 70 antibodies?
Anti–Scl-70 antibodies are considered a specific marker for the diffuse type of systemic sclerosis. However, these autoantibodies can be seen in SLE, ranging from 0% to 25% of patients with a mean of 4.1%.
Which is the best description of dermatosclerosis?
(sklerō-dĕrmă) Thickening and induration of the skin caused by new collagen formation, with atrophy of pilosebaceous follicles; either a manifestation of progressive systemic sclerosis or localized (morphea). Synonym(s): dermatosclerosis, systemic scleroderma.
What kind of skin condition is lipodermatosclerosis?
What is lipodermatosclerosis? Lipodermatosclerosis is a chronic inflammatory condition characterised by subcutaneous fibrosis and hardening of the skin on the lower legs. Lipodermatosclerosis is also known as sclerosing panniculitis and hypodermitis sclerodermaformis.
What kind of disease is systemic scleroderma?
systemic scleroderma a systemic disorder of the connective tissue characterized by hardening and thickening of the skin, with telangiectasias, Raynaud’s phenomenon, and fibrotic degenerative changes in organs such as the heart, lungs, kidneys, and gastrointestinal tract.
What kind of drugs are used for dermatosclerosis?
Treatment includes drugs such as penicillamine, immunosuppressives, and antiinflammatory agents. Ulcers that form on the knuckles, elbows, and other bony prominences as a result of calcium deposits are treated topically with ointments.