What is meant by sustained release drug delivery system?
Sustained release allows delivery of a specific drug at a programmed rate that leads to drug delivery for a prolonged period of time (Moghimi et al., 2001). This approach of drug release is especially useful for drugs that are metabolized too fast and are eliminated from the body shortly after administration.
What are sustained release preparations?
Sustained-release dosage forms are dosage forms designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects.
What is breakthrough capacity of ion exchange resin?
The average breakthrough capacity was found to be 2.17 mg NH4 per gram for the resin.
What is the characteristics of ion exchange resin drug complexes?
Ion exchange resins have specific properties like available capacity, acid base strength, particle size, porosity and swelling properties. The ion exchange resins are complexed with drug to form resinates by batch or column process.
What is the purpose of sustained release tablets?
Sustained release tablets are in a form of dosage where a drug is administered to a patient at a given or calculated rate with the aim of maintaining a certain concentration of the administered drug over a specific period of time into the patient’s system while reducing possible side effects.
Why do we need sustained release tablets?
Benefits of Sustained-Release Tablet Formulations Provides the ability to maintain a constant level of medication within the body. Eliminates the likelihood of burst drug release. Reduces the number of doses which lowers expenses and improves patient compliance, especially for chronic diseases. Decreases side effects.
What are sustained release drugs?
Sustained-release (or extended-release) drugs maintain drug release over a sustained period but not at a constant rate. Pulse-release drugs have a delayed-release to ensure that the drug is delivered at the right time or place in the patient’s body.
What are sustained release tablets?
How do you calculate resin capacity?
The softener capacity is calculated in three simple steps:
- Convert water hardness from ppm to grains per US gallon. Total Hardness (ppm) = Total Hardness (gpg) Example: 118 ppm TH = 6.9 gpg;
- Calculate softener capacity in grains.
- Calculate softener capacity in gallons.
- Table One: Tank Size and Resin Volume.
What is ion exchange capacity of an exchanger?
ion-exchange capacity, measure of the ability of an insoluble material to undergo displacement of ions previously attached and loosely incorporated into its structure by oppositely charged ions present in the surrounding solution.
How does a cation ion exchange resin release the drug in the gastrointestinal tract?
Drugs are bound to resin functional groups through weak ionic interactions and released by the exchange of a counter-ion. For example, an anionic resin with a cationic drug molecule attached will first enter the gastrointestinal tract and be exposed to cation in the gastric fluid such as sodium or potassium ions.
Which one of the following is the characteristics of ion exchange controlled release system?
Q11: What are the characteristics of ion exchange resin drug complexes? Explanation: Ionisable acidic and basic drugs are complexed with insoluble anion or cation exchange resins. The drug is released slowly by diffusion through the resin particle. Thus the controlled released of the drug is maintained.