What is K65R mutation?
K65R is a relatively rare drug resistance mutation (DRM) selected by the NRTIs tenofovir, didanosine, abacavir and stavudine and confers cross-resistance to all NRTIs except zidovudine. Selection by other NRTIs is uncommon.
What is genotypic resistance?
Genotypic resistance testing examines the genetic structure (genotype) of a patient’s HIV. A blood sample is taken from the patient, and the HIV is analyzed for the presence of specific genetic mutations that are known to cause resistance to specific drugs.
What is the contraindication of nevirapine?
Nevirapine can cause serious, life-threatening side effects. These include severe liver problems, skin rash, and skin reactions. Liver and skin problems can happen at any time during treatment with nevirapine, but your risk is greatest during the first 18 weeks of treatment.
What is the brand name for nevirapine?
VIRAMUNE is the brand name for nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Nevirapine is structurally a member of the dipyridodiazepinone chemical class of compounds.
What drug class does efavirenz belong to?
Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood.
When does k101h occur in combination with other NNRTI resistance mutations?
When it occurs in combination with other NNRTI-resistance mutations, K101H is associated with reduced susceptibility to NVP and EFV ( 10) and has a weight of 1.0 in the Tibotec ETR genotypic susceptibility score. K101Q is a minimally polymorphic accessory mutation weakly selected in patients receiving NVP and EFV ( 36 ).
Which is NRTI mutation reduces susceptibility to NVP and EFV?
K238T is a nonpolymorphic mutation selected in patients receiving NVP and EFV (3,23). It often occurs in combination with K103N (23). It reduces susceptibility to NVP and EFV by about 5-fold (32,3) and possibly reduces susceptibility to ETR and RPV (15,66).
Which is a minimally polymorphic accessory mutation not selected by NNRTI?
K101Q is a minimally polymorphic accessory mutation weakly selected in patients receiving NVP and EFV ( 36 ). It appears to have minimal, if any, detectable effect on NNRTI susceptibility ( 10 ). K101R is a polymorphic mutation that is not selected by NNRTIs ( 3 ). It has no effect on NNRTI susceptibility ( 10 ).