What is Dihydroartemisinin used for?
Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself.
How do you take Dihydroartemisinin Piperaquine?
Treatment and dosage Dihydroartemisinin-piperaquine (DHA/PQP) is administered once a day for 3 consecutive days. The dosage (quantity and number of tablets) to be taken in each administration depends on the patient’s body weight.
What is piperaquine phosphate?
Piperaquine is a bisquinoline antimalarial drug that was first synthesized in the 1960s and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years.
What is artemisinin based combination therapy?
Artemisinin-based combination therapies (ACTs) are the first-line therapy in almost all countries where malaria is endemic due to the high efficacy, tolerability, and ability of ACTs to reduce ongoing transmission of the parasite. ACTs are comprised of two components: an artemisinin derivative and a partner drug.
What are the side effects of P Alaxin?
P alaxin Suspension Side-effects
- Dizziness.
- Nausea.
- Anorexia.
- Abdominal pain.
- Diarrhea.
- Itching.
Does P Alaxin cause kidney failure?
(ET Olayinka et al., IOSR J of Pharm and Biol Sc Mar-April 2013) :” Our results suggest that the therapeutic doses of P-ALAXIN (DHA-piperaquine) induced marked renal and hepatic failure and decreased the levels of antioxidant defese systems, with the effect more pronounced in double therapeutic doses.
What is P Alaxin side effects?
Is piperaquine same as chloroquine?
Piperaquine (a slowly eliminated bisquinoline) combined with dihydroartemisinin is well tolerated and highly effective against chloroquine resistant vivax malaria and has replaced chloroquine as first-line treatment in Indonesia [4].
What is the side effect of piperaquine?
In the first human studies of piperaquine, the main side effects were mild headache, listlessness, nausea, and dizziness, and no patients died [8].
What are the drugs in artemisinin combination therapy?
Fast acting artemisinin-based compounds are combined with a drug from a different class. Companion drugs include lumefantrine, mefloquine, amodiaquine, sulfadoxine/pyrimethamine, piperaquine and chlorproguanil/dapsone. Artemisinin derivatives include dihydroartemisinin, artesunate and artemether.
How is dihydroartemisinin used in antimalarial treatment?
Dihydroartemisinin (DHA) is an antimalarial agent. Dihydroartemisinin treatment effectively up-regulates the cytosolic RelA/p65 protein level and down-regulates the nuclear RelA/p65 protein level. Dihydroartemisinin blocks the nuclear translocation of RelA/p65 from the cytosol rather than suppressing RelA/p65 protein synthesis.
What is the molecular weight of dihydroartemisinin?
Molecular Weight(MW): 284.35. Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
Which is the active metabolite of artemisinin artesunate?
Dihydroartemisinin. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs.
Which is a semi-synthetic derivative of artemisinin?
It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs. It is sold commercially in combination with piperaquine and has been shown to be equivalent to artemether/lumefantrine.