What is a CD1 mouse?
CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland. They were imported to the US in 1926 and to Charles River in 1959. The CD-1 IGS mice are generally used for genetics, toxicology, pharmacology, and aging research.
Are CD-1 mice outbred?
CD-1, an outbred mouse line derived from the original colony of Swiss mice started in 1926 ( 9 ), are commonly used in toxicology and in chemical carcinogenicity bioassays.
Is CD-1 a commonly used mouse strain?
Overview. CD1 IGS (also known as Crl:CD1(ICR)) is an albino outbred strain of mouse model that has frequently been used in toxicology and pharmacological research. It is the most popular strain of outbred mouse.
What is Swiss albino mice?
Swiss albino mice Mus musculus is a widely used mouse strain, which is used for many research investigations due to its small size, short life span, and easy maintenance. Successful mice breeding are crucial aspect of mice stock maintenance and many other experiments such as mating assay and fertility assessment.
What is the difference between inbred and outbred mice?
Genetically, there are two major classes of laboratory mice: inbred and outbred. Inbred mice are genetically homogeneous and there is very little variation or heterogeneity within a pure inbred strain. Outbred mice are bred specifically to maximize genetic diversity and heterozygosity within a population.
Are CD1 mice aggressive?
Male CD1 mice are described as aggressive and territorial24,40, even when housed in sibling groups26. Additionally, it is known that nest building material can decrease inter-male aggression29, specifically when transferred during cage change6,28.
Are albino mice rare?
In the wild, albinism in rodents is a rare condition, and it has been relatively poorly documented. Rodents represent 40% of the mammals species worldwide, but albino specimens have been reported in less than 2% of the species.
Why do white mice have red eyes?
The albino phenotype in mice (white hair and red eyes) arises from having homozygous mutant tyrosinase alleles (denoted as small “c”). Albino mice have melanocytes, but these cells are incapable of melanin synthesis. Therefore AA or Aa mice present as agouti, as long as they are also Cc or CC.
What are diversity outbred mice?
The Diversity Outbred (DO) stock is a genetically diverse mouse resource and may be used as a tool for high resolution genetic mapping and validation of previously identified quantitative trait loci (QTLs) linked to disease susceptibility, drug resistance or behavioral phenotypes.
Where did the CD-1 IGS mouse come from?
CD-1® IGS Mouse | Charles River Laboratories. The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland.
How are food and water intakes calculated for mice?
For each mouse, average daily food and water intakes were calculated. Intakes adjusted for body weight were derived by dividing average intakes by the average body weight and multiplying the result by 30 g (the approximate weight of an adult mouse, used as a correction factor in our previous studies).
Where did the HSD ICR mouse come from?
The Netherlands Israel Origin: The Hsd:ICR (CD-1®) mouse model is of Swiss origin and descended from the original two male and seven female albino non-inbred mice, imported by the Rockefeller Institute in 1926 from Lausanne, Switzerland.