What happens if disulfiram is administered with ethyl alcohol?
Disulfiram blocks this oxidation by inhibiting ALDH, causing a rapid rise of acetaldehyde in the blood when alcohol is consumed. The result is called a disulfiram-alcohol reaction, and it may increase the acetaldehyde concentration in blood to 5 to 10 times that occurring without disulfiram.
What is a disulfiram like reaction with alcohol?
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.
How do you deal with disulfiram like reactions?
Recommended treatment consists of supportive measures such as Trendelenberg posture, administration of oxygen and intravenous infusion of fluid, solute, colloid, and, if needed, a pressor agent such as norepinephrine. Iron salts, ascorbic acid, antihistamines and phenothiazines are of no established benefit.
What causes disulfiram ethanol reaction?
The disulfiram-ethanol reaction (DER) is due to increased serum acetaldehyde concentrations generated by the metabolism of ethanol by alcohol dehydrogenase in the liver. Normally, this acetaldehyde is cleared rapidly by its metabolism to acetate via aldehyde dehydrogenase.
Which of the following is known to cause disulfiram ethanol like reaction?
Which oral antidiabetic agent produces disulfiram-like?
In the present study, chloramphenicol, furazolidone, metronidazole, and quinacrine, which are reported to produce a disulfiram-like reaction, as well as disulfiram, were administered to Wistar rats and the hepatic activities of alcohol and aldehyde dehydrogenases (1A1 and 2) were determined.
Which of the following is known to cause disulfiram-ethanol like reaction?
Which oral antidiabetic agent produces disulfiram like?
Can a disulfiram-like reaction be caused by alcohol?
The association of disulfiram-like reaction with concomitant use of metronidazole and alcohol has been reported in the literature; however, alcohol containing oral liquids may not always be identified as a culprit.
Are there any antibiotics that cause similar reactions to disulfiram?
Abstract. In addition to disulfiram, some antibiotics can cause similar reaction as disulfiram-like reactions. A variety of antibiotics containing the fused β-lactam/dihydrothiazine ring system have been known as cephalosporin, and it was reported initially to adversely affect the metabolism of alcohol in 1980.
What happens if you take cephalosporin with disulfiram?
The manifestation of CIDLR (cephalosporin-induced disulfiram-like reaction) varies from mild reaction like facial flushing, nausea or vomiting, to a severe reaction including angioedema, hypotension, shock, or death. In addition to disulfiram, some antibiotics can cause similar reaction as disulfiram-like reactions.
Is there a disulfiram-like reaction with prednisone intensol?
A disulfiram-like reaction between the steroid solution and metronidazole was suspected; therefore, the Prednisone Intensol was discontinued. The patient’s mother reported that, following discontinuation, the patient slept well for the first time in 2 days.