What drug classification is vinblastine?
Vinblastine is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.
What is the purpose of vinblastine?
Vinblastine is used to treat Hodgkin’s disease, certain types of lymphoma, testicular cancer, breast cancer, choriocarcinoma (a type of uterine cancer), Kaposi’s sarcoma, and Letterer-Siwe disease. Vinblastine is often used in combination with other cancer medications.
How do you administer vinblastine?
Vinblastine should not be given intramuscularly, subcutaneously or intrathecally. The solution may be injected either directly into the vein or into the injection site of a running intravenous infusion. Injection of vinblastine sulfate may be completed in about one minute. FOR INTRAVENOUS USE ONLY.
What is the generic name for vinblastine?
Vinbastine is the generic name for the trade name drug Alkaban-AQ® or Velban®. In some cases, health care professionals may use the trade names Alkaban-AQ and Velban® or other names; such as VLB, Vinblastine Sulfate, or Vincaleukoblastine when referring to the generic drug name vinblastine.
When was vinblastine first used?
Vinblastine was isolated in 1958. An example of a natural herbal remedy that has since been developed into a conventional medicine, vinblastine was originally obtained from the Madagascar periwinkle. It is on the World Health Organization’s List of Essential Medicines….Vinblastine.
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| ATC code | L01CA01 (WHO) |
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What is vinblastine and curcumin?
Curcumin, a major component of curry powder, which is a natural polyphenol product extracted from rhizoma curcumae longae, interacts with a specific binding site on microtubules. Vinblastine is an antitumor drug that induces microtubule depolymerization.
What is the mechanism of action of vinblastine?
Mechanism of Action Vinblastine is the salt of an alkaloid extracted from a flowering herb commonly known as periwinkle. Vinblastine is cell cycle phase specific; it binds to microtubular proteins in the mitotic spindle, thereby preventing cell division during metaphase.
Who invented vinblastine?
Abstract. In 1995, Canadian scientists Robert Noble and Charles Beer were in- ducted into the Canadian Medical Hall of Fame for their 1950s “discovery” of Vinblastine.
How does the drug vinblastine affect mitosis?
Both vincristine and vinblastine bind to the microtubular proteins of the mitotic spindle and prevent cell division during the anaphase of mitosis. They arrest mitosis and cause cell death. The drugs are therefore M-phase cell-cycle specific and their effects are therefore limited to dividing cells.
What kind of drug is vinblastine used for?
Drug type: Vinblastine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid.” (For more detail, see “How vinblastine works” section below). What Vinblastine Is Used For:
How often should I take vinblastine for cancer?
Vinblastine comes as a powder or solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once a week. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.
Are there any side effects to taking vinblastine?
The following side effects are common (occurring in greater than 30%) for patients taking vinblastine: Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia and/or bleeding.
Can you take vinblastine sulfate as a single agent?
Therefore, although Vinblastine sulfate is effective as a single agent in the aforementioned indications, it is usually administered in combination with other antineoplastic drugs. Such combination therapy produces a greater percentage of response than does a single-agent regimen.