What does urocortin do?
Urocortin has been shown to induce increases in heart rate and coronary blood flow when applied peripherally. These effects are likely mediated through the CRF type 2 receptor, as this receptor is found in the cardiac atria and ventricles. Urocortin also functions to protect cardiovascular tissue from ischemic injury.
What is urocortin 1?
Urocortin-1 (Ucn-1), a member of the corticotropin-releasing factor family, has been shown in animal studies to have effects on the pituitary-adrenal axis, the cardiovascular system, circulating neurohormones, and renal function and to suppress appetite.
Is CRF a peptide?
CRF was identified in 1981 as a 41-aa hypothalamic peptide stimulating the release of ACTH and β-endorphin from the anterior part of the pituitary gland (Vale et al., 1981).
Is CRF a protein?
Signaling and pharmacology of CRF receptors CRF-Rs belong to the family of G-protein-coupled receptors (GPCRs).
Is CRF a neurotransmitter?
Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. This study supports the concept that CRF functions as a neurotransmitter in the LC in the initiation of stress responses.
What is CRF Gene?
Tocris Summary for CRH Gene Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival.
Where is CRF1 found?
Both of the characterized members of the CRF receptor family (CRF1 and CRF2), are found in the amygdala, site of origin of CRF-induced seizures, and may therefore mediate these seizures.
What is CRF cortisol?
Corticotropin releasing factor (CRF) is a hypothalamic hormone, which acts on the anterior pituitary to stimulate the secretion of corticotropin, thereby regulating the synthetic/secretory activity of the adrenal cortex Vale et al (1981).
What are CRF receptors?
The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors.