What does propofol do to animals?
Propofol can be used for sedation, induction of anesthesia, and maintenance of anesthesia in small animal patients. In all these situations recovery from its effects is typically rapid and smooth.
How long does it take for propofol to wear off in dogs?
In preanesthetized dogs (phenothiazine/opioid or benzodiazepine/opioid), maintenance anesthesia averages 5.0-5.4 minutes after each maintenance dose. Recovery from propofol is rapid; full standing recovery is generally observed within 20 minutes. The use of certain premedicants may result in prolonged recovery.
What are the potential side effects of propofol and its formulations?
Despite the success of propofol emulsions, drawbacks to such formulations include inherent emulsion instability, injection pain, a need for antimicrobial agents to prevent sepsis, and a concern of hyperlipidemia-related side effects.
Does propofol have long term side effects?
The distinct adverse-effect profile of long-term use of propofol, including hypertriglyceridemia, was evaluated and reported as significant. Conclusion: The limited data available suggest that long-term infusion of propofol is a practical alternative to use of standard agents for sedation of intubated patients.
Is propofol safe for cats?
Preliminary data concluded the presence of 2% benzyl alcohol in the formulation of propofol did not cause significant morbidity and mortality under excessive and repeat dose conditions in cats.
Can you use propofol in cats?
GENERAL ANESTHESIA. The injectable drugs commonly used for anesthetic induction and complete immobilization in cats include, thiopental, ketamine/diazepam or midazolam (1:1) mixtures, propofol, and alfaxalone. Sedation prior to induction is important to minimize the amount of the injectable agent required.
Can cats have propofol?
When used according to the FDA-approved label, alfaxalone is more or less interchangeable with propofol. The anesthetic and physiologic effects are clinically similar; both drugs provide smooth and effective induction of anesthesia in cats.
Can propofol cause phlebitis?
Transient phlebitis induced by a bolus injection of propofol. It is associated with a transient, local venodilation and additional inflammation or irritation, attributed to infusion by propofol.
Does propofol affect brain?
Accumulating evidence suggest that propofol-induced unconsciousness is associated with a global metabolic and vascular depression in the human brain and especially with a significant reduction in the thalamocortical network and the frontoparietal network.
What are the side effects of propofol for dogs?
When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The primary side effect of propofol is respiratory depression as evidenced by tachypnea and apnea.
Can a veterinarian give an injection of propoflo?
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. PropoFlo™ Injection is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. Propofol is chemically described as 2, 6-diisopropylphenol and has a molecular weight of 178.27.
What happens to your body when you take propofol?
Physiological effects: Mild hypotension may occur during propofol anesthesia. 4. Premedicants: Premedicants may increase the anesthesia or sedative effect of propofol and result in more pronounced changes in systolic, diastolic and mean arterial blood pressures. 5.
What is the molecular weight of propoflo injection?
PropoFlo™ Injection is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. Propofol is chemically described as 2, 6-diisopropylphenol and has a molecular weight of 178.27.