What does high eosinophil Cationic protein mean?
Background: Eosinophil cationic protein (ECP) is a potent cytotoxic secretory protein with bactericidal and antiviral properties. ECP is released by activated eosinophils and regarded as a marker of eosinophilic inflammation. High levels of ECP have been reported in cases of active asthma and other allergic diseases.
What is ECP lab?
Eosinophil Cationic Protein (ECP) – UNICAP ECP is an invitro test system for quantitative measurement of Eosinophil Cationic Protein (ECP) in human serum. Determination of ECP levels in human sera is important to diagnose a viariety of allergic disorders and other clinic conditions connected with activated eosinophils.
What are eosinophils and what do they do?
Eosinophils are major effector cells in the immune system. They have a beneficial role in host defence against nematodes and other parasitic infections and are active participants in many immune responses. However, eosinophils can also be damaging as part of the inflammatory process of allergic disease.
What does eosinophil cationic protein do?
ECP is a mediator in host immune response to parasites, bacteria and viruses. By its cytotoxic and non-cytotoxic activity, ECP may also cause side-effects in the host’s own tissues. The largest number of clinical studies is focused on the role of ECP in eosinophil-related disorders, particularly in asthma.
What is eosinophilic inflammation?
When you have eosinophilic asthma, you have inflammation in your respiratory system caused by cells called eosinophils. Eosinophils are white blood cells. They’re part of your body’s immune system, and normally, they help you fight disease. One of their jobs is to help cause swelling.
What is urine eosinophil?
Eosinophils are white blood cells that normally do not appear in urine. The presence of eosinophils in the urine is seen in acute interstitial nephritis, which is caused by an allergic reaction, typically to drugs.
Are proteins eosinophilic?
Eosinophilic describes the appearance of cells and structures seen in histological sections that take up the staining dye eosin. This is a bright-pink dye that stains the cytoplasm of cells, as well as extracellular proteins such as collagen. Such eosinophilic structures are, in general, composed of protein.
What are eosinophils in a blood test?
Eosinophils are a type of disease-fighting white blood cell. This condition most often indicates a parasitic infection, an allergic reaction or cancer. You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia).
What are the symptoms of interstitial nephritis?
Symptoms of interstitial nephritis
- Increased urine output.
- Blood in your urine or dark urine.
- Nausea or vomiting.
- Fever or rash.
- Elevated blood pressure.
- Changes in mental status, such as drowsiness or confusion.
- Swelling of any area of your body.
- Sudden weight gain. This can be caused by extra fluid in the body.
What kind of protein is found in eosinophils?
Use. Eosinophils are effector cells that play a role in allergic and nonallergic inflammation. 1,2 The most prominent feature of these cells is large cytoplasmic granules, each containing four basic proteins, the most plentiful of which is eosinophil cationic protein (ECP). 3 ECP is a protein with ribonuclease activity that is released
What is the CPT for eosinophil cationic protein?
Eosinophil Cationic Protein (ECP) TEST: 004180 CPT: 86849
Where is ribonuclease 3 located in the eosinophil matrix?
Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix.
Where do eosinophils accumulate in the lung after exposure?
Allergic reactions in the lung typically have two phases. The late phase typically occurs several hours after exposure, upon which eosinophils accumulate in the bronchus and release granule proteins that cause bronchial irritability. ECP is also toxic to neurons, some epithelial cell lines, and isolated myocardial cells.