What does erythropoiesis produce?
Erythropoiesis (from Greek ‘erythro’ meaning “red” and ‘poiesis’ “to make”) is the process which produces red blood cells (erythrocytes), which is the development from erythropoietic stem cell for mature red blood cell.
What is the process of erythropoiesis?
Specifically, erythropoiesis is the process by which red blood cells (erythrocytes) are produced. Erythrocytes arise from a complex line of cells, and their rate of production is tightly regulated to ensure adequate but not excessive numbers of red blood cells are produced.
Where is the production of erythropoietin?
kidney
The major site of Epo production is the kidney, while the liver is the main extrarenal site of Epo production. Within these organs, the cells synthesizing Epo were identified by using in situ hybridization in hypoxic animals with an increased Epo mRNA expression.
What are the production cells for erythropoietin?
Within the kidney, erythropoietin is produced by interstitial fibroblast-like cells that surround the renal tubules.
Which is the most common theory of erythropoiesis?
Theories of erythropoiesis Monophyletic theory – Also known as unitary theory. – There is a common parent cell of all formed elements of blood. Polyphyletic theory – Also known as trialistic theory – Suggests different group of stem cells gives rise to different blood cells.
What is the role of EPO in erythropoiesis?
Erythropoietin (EPO) is the key hormone responsible for effective erythropoiesis, and iron is the essential mineral required for hemoglobin production. EPO allows survival and proliferation of erythroid precursor cells by generating intracellular signals resulting in the prevention of apoptosis.
Where does erythropoiesis take place after 20 years?
After the age of 20 years, RBCs are produced from membranous bones such as vertebrae, the sternum, ribs, scapulas, and the iliac bones. After 20 years of age, the shaft of the long bones becomes yellow bone marrow because of fat deposition and loses the erythropoietic function.
When does the production of erythropoietin increase?
When the number of circulating red cells decreases or when the oxygen transported by the blood diminishes, an unidentified sensor detects the change and the production of erythropoietin is increased. This substance is then transported through the plasma to the bone marrow, where it accelerates the production of red cells.