What did Roger Tsien discover?
He was a professor of chemistry and biochemistry at the University of California, San Diego and was awarded the Nobel Prize in Chemistry for his discovery and development of the green fluorescent protein, in collaboration with organic chemist Osamu Shimomura and neurobiologist Martin Chalfie.
How did Dr Roger Tsien’s Nobel Prize winning work affect our understanding of proteins?
Dr. Tsien and the other members of his laboratory mutated the gene so that the proteins glowed brighter under blue light, which made them easier for biologists to use. (Ultraviolet light damages living cells.)
Where was Tsien born?
New York, NY
Roger Y. Tsien/Place of birth
What is green fluorescent protein used for?
Biologists use GFP to study cells in embryos and fetuses during developmental processes. Biologists use GFP as a marker protein. GFP can attach to and mark another protein with fluorescence, enabling scientists to see the presence of the particular protein in an organic structure.
When was GFP cloned?
1992
Because of its low molecular weight and ability to fluoresce independently (George, 1997), the new molecular tag, green fluorescent protein (GFP), has become more and more popular after Prasher et al. (1992) cloned its cDNA in 1992.
Who founded GFP?
Osamu Shimomura
Osamu Shimomura first isolated GFP from the jellyfish Aequorea victoria, which drifts with the currents off the west coast of North America. He discovered that this protein glowed bright green under ultraviolet light.
What does Tsien mean?
Tsien is a last name commonly found in United States among its Chinese community. It is the Cantonese transliteration of a Chinese surname meaning: coin, money, unit of weight, one tenth of a tael 兩|两[liang3]. Related Surnames: Chee, Chi, Chien, Chin, Qian, Tsin, Zee.
What was the cause of Roger Tsien’s death?
On August 31, 2016, a press release by UC San Diego announced the death of Prof. Tsien. He died on August 24, 2016. Although the actual cause of death is yet to be determined, he seemed to have died while on a bike trail in Eugene, Oregon. Prior to his death, Tsien had survived cancer and suffered a stroke in 2013.
When did Roger Tsien win the Nobel Prize?
Roger Yonchien Tsien ( Chinese: 錢永健; February 1, 1952 – August 24, 2016) was an American biochemist. He was a professor of chemistry and biochemistry at the University of California, San Diego and was awarded the 2008 Nobel Prize in Chemistry for his discovery and development of the green fluorescent protein,…
What kind of tools does Roger Tsien use?
The Tsien lab creates versatile tools that enable visual examination of cell signaling and disease processes. Most of their recent work concerns activatable cell-penetrating peptides (ACPPs), which allow detection of enzyme activities or other reactive species in living systems.
Who are some of Roger Tsien’s former trainees?
Tsien mainly contributed to much of our understanding of how GFP works and for developing new techniques and mutants of GFP. Former trainees of Roger Y. Tsien include Atsushi Miyawaki and Alice Y. Ting . Timelines of GFP-development involved by Tsien: